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Indian scientists isolate Candida auris in the environment

A team of Indian scientists yesterday reported the detection of Candida auris isolates from two sampling sites on islands in the Indian Ocean—the first time the multidrug-resistant yeast has been isolated in a natural environment. The discovery was reported in mBio.

Study shows deeper COVID impact in socially vulnerable neighborhoods

An analysis of neighborhood-level data in three US cities highlights the racial and socioeconomic disparities in COVID-19 positivity, incidence, and mortality, researchers reported today in the Annals of Internal Medicine.

ReAct report lays out challenges, solutions for antibiotic access

A new report from antibiotic research and development (R&D) advocacy group ReAct outlines the challenges and solutions for creating a new model that will deliver sustainable access to antibiotics for all countries.

Our weekly wrap-up of antimicrobial stewardship & antimicrobial resistance scans

ReAct report lays out challenges, solutions for antibiotic access

Originally published by CIDRAP News Apr 1

A new report from antibiotic research and development (R&D) advocacy group ReAct outlines the challenges and solutions for creating a new model that will deliver sustainable access to antibiotics for all countries.

Hospitals worldwide display wide variation in antibiotic consumption

A worldwide analysis of hospital antibiotic prescribing patterns found considerable differences between countries and regions in proportional use of Access, Watch, and Reserve (AWaRe) antibiotics, researchers reported today in the Journal of Antimicrobial Chemotherapy.

CARB-X awards funding for rapid sexually transmitted infections test

CARB-X announced today that it is awarding up to $3.6 million in funding to Novel Microdevices, Inc. of Baltimore to develop a rapid, portable molecular diagnostic test for sexually transmitted bacterial infections.

European health groups release antimicrobial resistance declaration

Health First Europe (HFE) and the European Patient Group on Antimicrobial Resistance (AMR Patient Group) today launched their 2021 Declaration on AMR.

Australian study links rapid flu tests to reduction in antibiotic prescribing

Antibiotics were initiated less frequently, and antivirals used more frequently, in patients diagnosed as having influenza using rapid polymerase chain reaction (RPCR) tests compared with standard multiplex PCR (MPCR) tests, Australian researchers reported yesterday in BMC Infectious Diseases.

Our weekly wrap-up of antimicrobial stewardship & antimicrobial resistance scans

Australian study links rapid flu tests to reduction in antibiotic prescribing

Originally published by CIDRAP News Apr 8

Audit and feedback, prior approval may reduce fluoroquinolone use

A study of Veterans Affairs (VA) hospitals found that prospective audit and feedback (PAF) and prior-approval strategies focused on fluoroquinolone use were associated with lower fluoroquinolone prescribing rates, US researchers reported today in Infection Control & Hospital Epidemiology.

Antibiotic prescribing fell in British Columbia during pandemic

Overall and respiratory tract infection (RTI)-specific antibiotic prescribing fell significantly in British Columbia during the first few months of the COVID-19 pandemic, according to a study today in Open Forum Infectious Diseases.

ED stewardship intervention tied to reduced prescribing for viral infections

A pilot trial conducted at two emergency departments (EDs) found that audit and feedback with peer-to-peer comparisons reduced antibiotic prescribing for viral acute respiratory infections (ARIs) but not overall antibiotic use, researchers reported today in Open Forum Infectious Diseases.

MRSA hospital return tied to extensive antibiotic exposure, C diff infection

Secondary analysis of patients from a postdischarge decolonization trial of methicillin-resistant Staphylococcus aureus (MRSA) carriers found that re-hospitalization for MRSA was associated with extensive exposure to non-MRSA antibiotics and Clostridioides difficile infection (CDI), researchers reported today in Infection Control & Hospital Epidemiology.

Our weekly wrap-up of antimicrobial stewardship & antimicrobial resistance scans

CARB-X to fund development of bacteriophage-based drug

CARB-X announced today that it is awarding Phico Therapeutics of Cambridge, United Kingdom, up to $5.3 million to develop an intravenous bacteriophage drug to treat ventilator-associated pneumonia caused by Pseudomonas aeruginosa.

Rapid diagnostic for neonatal sepsis receives CARB-X funding

CARB-X announced today that it is awarding Durham, North Carolina, biotech company Baebies Inc. up to $3.9 million to develop a rapid, easy-to-use diagnostic test for sepsis in newborns.

Risk factors, mechanisms noted in colistin-resistant Enterobacterales

A study of colistin-resistant Enterobacterales (CORE) isolates from patients in southeast Michigan found that increased age and prior antibiotic receipt were associated with increased risk of CORE colonization or infection, researchers reported today in Open Forum Infectious Diseases.

Phase 2 trial shows high efficacy for malaria vaccine candidate

The results of a phase 2b clinical trial indicate 77% efficacy over 12 months of follow-up for a vaccine that targets malaria caused by Plasmodium falciparum, according to a preprint study published this week in The Lancet.

Our weekly wrap-up of antimicrobial stewardship & antimicrobial resistance scans

Study finds high broad-spectrum antibiotic use in Indonesian hospitals

A point-prevalence study (PPS) conducted in six Indonesian hospitals found a high rate of empirical use of broad spectrum antibiotics, researchers reported today in JAC-Antimicrobial Resistance.

CARB-X to fund development rapid diagnostic test for sepsis

CARB-X announced today that it is awarding up to $3 million to GenomeKey of Bristol, United Kingdom, to develop an innovative rapid diagnostic test for sepsis.

ASP network boosts stewardship activity at community hospitals

Community hospitals participating in a collaborative network focused on antibiotic stewardship program (ASP) implementation saw an increase in ASP activities and a decline in antibiotic use over 42 months, researchers reported yesterday in Clinical Infectious Diseases.

CDC: 2020 Sturgis Motorcycle Rally a COVID-19 super-spreader event

The August 2020 Sturgis Motorcycle Rally in South Dakota spread COVID-19 across the country, resulting in at least 649 infections—including transmission to household and workplace contacts—over the next 6 weeks, according to a study today in Clinical Infectious Diseases.

PhRMA report highlights challenges to antibiotic development

A new report from the pharmaceutical industry shows there are nearly 90 drugs in clinical development against drug-resistant infections—not nearly enough to meet the growing challenge of antimicrobial resistance (AMR).

Our weekly wrap-up of antimicrobial stewardship & antimicrobial resistance scans

PhRMA report highlights challenges to antibiotic development

A new report from the pharmaceutical industry shows there are nearly 90 drugs in clinical development against drug-resistant infections—not nearly enough to meet the growing challenge of antimicrobial resistance (AMR).