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Bipartisan group of lawmakers urges more funding for AMR response

A bipartisan group of congressional representatives called on House appropriators last week to increase funding for the federal response to antimicrobial resistance (AMR).

CARB-X to fund development of novel antibiotic for CRE infections

CARB-X announced today that it is awarding up to $4.1 million to Summit Therapeutics of Cambridge, Massachusetts, to develop a first-in-class antibiotic to treat multidrug-resistant bacterial infections.

CARB-X funds development of novel antibiotic for gram-negative infections

CARB-X announced today that it is awarding Swiss drug maker Basilea Pharmaceutica International up to $2.7 million to develop a novel class of antibiotics to treat gram-negative bacterial infections.

Pneumococcal vaccines may affect use of kids' antibiotics

Antibiotic prescribing for young children in Israel sharply declined following implementation of pneumococcal conjugate vaccine (PCV), Israeli researchers reported today in Clinical Infectious Diseases.

High level of antibiotic use found in dying organ donors

In a first-of-its-kind study, a team of US researchers reported this week in Clinical Infectious Diseases that nearly all of more than 400 deceased organ donors received at least one antibiotic dose during their terminal hospitalization, a finding that study authors say highlights the need for antibiotic stewardship in this population.

Our weekly wrap-up of antimicrobial stewardship & antimicrobial resistance scans

Rapid test linked to quicker optimal therapy for blood infections

Implementation of a test that provides rapid bacterial identification and susceptibility results from positive blood cultures shortened the time to optimal antibiotic therapy and reduced unnecessary antibiotic exposure in hospitalized patients with bacteremia, researchers reported late last week in the Journal of Antimicrobial Chemotherapy.

Dentists may have fewer COVID-19 infections than other health workers

Monthly dentist surveys showed a cumulative infection rate of 2.6%, according to a study yesterday in the Journal of the American Dental Association (ADA). The researchers say these rates are lower than those in other health workers, such as physicians or emergency medical service professionals.

More US nursing homes using antibiotic stewardship elements

An analysis of US nursing home surveys shows substantial progress in antibiotic stewardship element implementation, researchers with the Centers for Disease Control and Prevention (CDC) reported today in Infection Control & Hospital Epidemiology.

CARB-X to fund development of CRISPR-based drug for E coli infections

CARB-X announced today that it is awarding up to $3.9 million to a Danish microbiome biotechnology company to develop a CRISPR-based drug to prevent Escherichia coli infections in cancer patients.

GARDP urges nations to strengthen response to drug resistance

The Global Antibiotic Research and Development Partnership (GARDP), on behalf of the Drugs for Neglected Diseases initiative, issued a statement this week that called on World Health Organization (WHO) member states to strengthen their responses to antimicrobial resistance (AMR).

Our weekly wrap-up of antimicrobial stewardship & antimicrobial resistance scans

GARDP urges nations to strengthen response to drug resistance

The Global Antibiotic Research and Development Partnership (GARDP), on behalf of the Drugs for Neglected Diseases initiative, issued a statement this week that called on World Health Organization (WHO) member states to strengthen their responses to antimicrobial resistance (AMR).

CARB-X funds novel antibiotics for multidrug-resistant pathogens

CARB-X announced today that it is awarding Swiss pharmaceutical company BioVersys up to $4.35 million to develop a new class of antibiotics to treat life-threatening infections caused by multidrug-resistant bacteria.

Study identifies metrics tied to respiratory infection antibiotic overuse

More than two thirds of antibiotics prescribed for respiratory tract infections at primary care practices within an academic health system were inappropriate, with unnecessary prescribing strongly linked to respiratory infections that almost never require antibiotics, researchers reported today in Infection Control & Hospital Epidemiology.

Antibiotic guidelines for COVID patients linked to reduced prescribing

Guidelines for antibiotic initiation and discontinuation for community-acquired bacterial pneumonia (CABP) in COVID-19 patients at a Chicago hospital were associated with reduced antibiotic prescribing and days of therapy (DOT), researchers reported yesterday in BMC Infectious Diseases.

US hospital data show nearly 80% of COVID-19 patients get antibiotics

Nearly 80% of US patients hospitalized for COVID-19 received antibiotics from March through October 2020, researchers from the Centers for Disease Control and Prevention (CDC) reported yesterday in Open Forum Infectious Diseases.

Our weekly wrap-up of antimicrobial stewardship & antimicrobial resistance scans

US hospital data show nearly 80% of COVID-19 patients get antibiotics

Nearly 80% of US patients hospitalized for COVID-19 received antibiotics from March through October 2020, researchers from the Centers for Disease Control and Prevention (CDC) reported yesterday in Open Forum Infectious Diseases.

Trial of rapid respiratory tests finds no reduction in antibiotics

The use of rapid respiratory pathogen (RRP) testing among children with influenza-like illness (ILI) did not reduce antibiotic prescribing, according to a randomized clinical trial published late last week in JAMA Network Open.

CARB-X to fund development of rapid diagnostic test for sepsis

CARB-X announced today that is awarding Tucson, Arizona–based Accelerate Diagnostics $578,000 to develop a diagnostic test for sepsis based on new fiber optic technology.

FDA finalizes guidance for topical, injectable antibiotics used in animals

The Food and Drug Administration (FDA) announced today that it has finalized guidelines to bring the remaining medically important antibiotics still sold over-the-counter (OTC) for use in animals under the supervision of veterinarians.

New WHO documents focus on tailored antimicrobial stewardship

The World Health Organization (WHO) this week released three new documents that aim to address antimicrobial resistance (AMR) through a behavioral insights approach.

Our weekly wrap-up of antimicrobial stewardship & antimicrobial resistance scans

New WHO documents focus on tailored antimicrobial stewardship

The World Health Organization (WHO) this week release three new documents that aim to address antimicrobial resistance (AMR) through a behavioral insights approach.

US lawmakers re-introduce the PASTEUR Act

US lawmakers today re-introduced a bill to reinvigorate the antibiotic development market.

Korean study details risk factors for drug-resistant organisms in COVID patients

Multidrug-resistant organisms (MDROs) were isolated in more than a quarter of South Korean patients with confirmed COVID-19 pneumonia and microbial culture results, with corticosteroid use identified as a significant risk factor, researchers reported yesterday in the American Journal of Infection Control.

Outpatient antibiotic durations frequently longer than needed, study finds

Nearly 40% of outpatient antibiotic prescriptions in an integrated healthcare system in Denver were longer than necessary, researchers reported yesterday in Open Forum Infectious Diseases.