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Study finds little menstrual cycle change after COVID vaccination

Despite anecdotal reports of alternations in menstrual cycle following COVID-19 vaccination, a study looking at the connection found little impact. A research team based at Oregon Health & Science University published their findings this week in Obstetrics & Gynecology.

Our weekly wrap-up of antimicrobial stewardship & antimicrobial resistance scans

Study describes outbreak of highly resistant, deadly Klebsiella in India

Indian researchers yesterday reported on a hospital outbreak of two strains of extensively drug-resistant Klebsiella pneumoniae. Their findings appeared in Antimicrobial Resistance and Infection Control.

Review finds too few innovative drugs in antibiotic development pipeline

A new review of the antibiotic development pipeline finds that there are relatively few clinically differentiated products in late-stage clinical development, especially against critical, multidrug-resistant pathogens, an international team of researchers reported yesterday in Antimicrobial Agents and Chemotherapy.

Study highlights inappropriate prescribing for respiratory infections

A study of 42 million US patient visits for antibiotic-inappropriate acute respiratory infections (ARIs) found that more than 10% received an antibiotic prescription, with providers in urgent care clinics and southern states among the most likely prescribers, US researchers reported this week in Infection Control & Hospital Epidemiology.

CRISPR-based E coli drug gets go-ahead for first human trial

Danish microbiome technology company SNIPR Biome ApS announced this week that the US Food and Drug Administration has approved the company's application to initiate the first human clinical trial of its CRISPR-based drug for preventing Escherichia coli infections in cancer patients.

Mixed results in trial of fosfomycin for bacterimic urinary tract infections

A randomized clinical trial found that fosfomycin did not demonstrate noninferiority to comparator antibiotics for bacteremic urinary tract infections (bUTIs) caused by multidrug-resistant (MDR) Escherichia coli, but it could remain an option for select patients, researchers reported yesterday in JAMA Network Open.

Our weekly wrap-up of antimicrobial stewardship & antimicrobial resistance scans

Study indicates stewardship helped reduce pediatric vancomycin use

A quality improvement (QI) program combining clinician education, clear and concise recommendations, and decision support was associated with a safe reduction in vancomycin use in a pediatric intensive care unit (PICU), researchers reported today in Pediatrics.

Our weekly wrap-up of antimicrobial stewardship & antimicrobial resistance scans

Study indicates stewardship helped reduce pediatric vancomycin use

A quality improvement (QI) program combining clinician education, clear and concise recommendations, and decision support was associated with a safe reduction in vancomycin use in a pediatric intensive care unit (PICU), researchers reported today in Pediatrics.

World Economic Forum warns of future risk, costs from waterborne AMR

A new report from the World Economic Forum predicts a future of rising risks and costs from waterborne antimicrobial resistance (AMR).

Survey: Those with minor symptoms more likely to OK delayed antibiotics

Severity and the type of symptoms experienced appear to be the biggest factors in accepting a delayed antibiotic prescription for a respiratory tract infection (RTI), according to a UK survey published yesterday in PLOS Medicine.

Vietnamese study finds benefits from CRE screening in newborns

Admission screening for carbapenem-resistant Enterobacterales (CRE) at a Vietnamese children's hospital was associated with reduced CRE acquisition, hospital-acquired infections (HAIs), duration of hospital stay, and costs, according to a study published this week in Antimicrobial Resistance and Infection Control.

Survey shows COVID-19 reduced AMR resources across 73 countries

A survey across 73 countries assessing the impact of COVID-19 on the prevention and control of antimicrobial resistance (AMR) highlights reduced availability of nursing, medical, and public health staff for AMR efforts. The study was published today in the Journal of Antimicrobial Chemotherapy.

Our weekly wrap-up of antimicrobial stewardship & antimicrobial resistance scans

Study describes impact of XDR typhoid on young children

A new study by researchers in Pakistan details the impact and response to treatment among children diagnosed as having extensively drug-resistant (XDR) typhoid infections.

VA study finds faster receipt of antibiotics in sepsis patients

A study of US veterans hospitalized with community-acquired sepsis shows an overall decline in time-to-antibiotics, with significant variation across hospitals, researchers reported this week in JAMA Network Open.

Our weekly wrap-up of antimicrobial stewardship & antimicrobial resistance scans

VA study finds faster receipt of antibiotics in sepsis patients

Originally published by CIDRAP News Sep 9

A study of US veterans hospitalized with community-acquired sepsis shows an overall decline in time-to-antibiotics, with significant variation across hospitals, researchers reported this week in JAMA Network Open.

NDM-producing Enterobacterales levels rising in Switzerland

Researchers in Switzerland have identified an increase in New Delhi metallo-beta-lactamase (NDM)–producing Enterobacterales, according to a report published today in Emerging Infectious Diseases.

CDC launches antibiotic stewardship toolkit for healthcare payers

The Centers for Disease Control and Prevention (CDC) yesterday launched a toolkit to help healthcare payers support appropriate antibiotic use in outpatient settings.

Phase 3 trial shows safety, high efficacy of typhoid conjugate vaccine

A phase 3 clinical trial conducted in Malawi has found that a single dose of typhoid conjugate vaccine (TCV) is safe and more than 80% effective at protecting children against typhoid fever, an international team of researchers reported yesterday in the New England Journal of Medicine.

Our weekly wrap-up of antimicrobial stewardship & antimicrobial resistance scans

Salmonella outbreak sickens 127 in 25 states; cake mix E coli probe ends

A rapidly growing Salmonella Oranienburg outbreak linked to an unknown food source has sickened 127 people, some of them part of restaurant clusters, from 25 states, the US Centers for Disease Control and Prevention (CDC) said in a Sep 17 announcement.

Canadian study finds high antimicrobial use in preterm infants

A study of preterm newborns in Canada found high rates of antimicrobial use in the first 7 days after birth, researchers reported last week in Infection Control & Hospital Epidemiology.

Fluoroquinolones tied to increased risk of acute liver injuries

A nationwide cohort study in Sweden found a twofold increased risk of acute liver injuries (ALIs) associated with oral fluoroquinolones in the first 2 months after starting treatment, researchers reported this week in Clinical Infectious Diseases.

Study: COVID had mixed impact on US outpatient antibiotic use

A review of national prescription drug data finds a mixed picture on US outpatient antibiotic use in 2020, researchers reported yesterday in JAMA Network Open.