After surging during the pandemic, rates of carbapenem-resistant gram-negative bacteria in critically ill patients have declined but remain higher than pre-pandemic rates.
The Italian government will contribute $21 million over 3 years to support CARB-X’s efforts to advance early-stage development of innovative new products for drug-resistant pathogens.
The study authors say knowledge about antibiotic-related harms will help patients, providers, and antibiotic stewardship programs.
Researchers found that a daptomycin-resistance mutation in vancomycin-resistant Enterococcus faecium is linked to use of rifaximin, an antibiotic prescribed for patients with liver cirrhosis.
Using data on factors such as water quality and public health spending, researchers were able to estimate antimicrobial resistance (AMR) rates in countries lacking AMR surveillance data.
The RENOFARM initiative aims to work with governments, farmers, and other stakeholders to reduce the use of antimicrobials in livestock production.
The multisite collaborative was associated with improved antibiotic prescribing for pediatric pneumonia, skin and other soft-tissue infections, and urinary tract infections.
Uncooked chicken had the highest levels of antibiotic-resistant E coli, with similar levels found in chicken-based raw dog food.
More than 75% of carbapenem-resistant Acinetobacter baumannii isolates collected from patients in 9 states were defined as difficult to treat.
The point-prevalence survey of European hospitals also found that 1 in 3 microorganisms detected in HAIs were resistant to antibiotics.
Wellcome, the Novo Nordisk Foundation, and the Bill & Melinda Gates Foundation will each donate $100 million to the joint initiative.
Data from 152 countries show use of antimicrobials in food-producing animals climbed by 2% from 2019 to 2021.
The Global AMR Diary will collect the stories of patients, parents, providers, and others affected by drug-resistant bacterial infections.
The plan aims to reduce antimicrobial use in people and animals, promote stewardship, and stimulate development of new drugs and vaccines.
The project asks adopters to commit to antimicrobial stewardship principles developed by the International Poultry Council.
The guidelines aim to prevent bloodstream infections caused by poor practices in the insertion, maintenance, and removal of peripheral intravenous catheters.
Researchers say the findings could help hospitals develop targeted hand-hygiene interventions.
A review and meta-analysis found that 15% of gram-negative bacterial isolates in India were resistant to the last-resort antibiotics.
Broad-spectrum antibiotic use was notably higher among cancer patients in the final months of life.
The report from the Global Coalition on Aging calls on G7 countries to contribute their 'fair share' to incentive structures to develop new antibiotics.
More than a quarter of ED visits had inappropriate antibiotic prescriptions, and nearly half of those didn't even have a plausible indication for antibiotics.
A total of 76% of patients were prescribed antibiotics.
The report suggests that policies to address AMR and its impacts need to take these factors into account.
Infants whose mothers received intrapartum azithromycin had a higher prevalence of azithromycin-resistant E coli and Klebsiella pneumoniae compared with those who received placebo.
A review and meta-analysis of 70 studies found a 19% reduction in antibiotic initiation and 20% reduction in antibiotic days of therapy in neonatal intensive care units.
