The funding will help the company develop a slow-release version of zaloganan, an investigational broad-spectrum anti-bacterial and anti-biofilm peptide.
Analysis of the intervention, implemented at 49 urgent care clinics, found the biggest reductions among clinicians who were actively engaged.
Clarametyx Biosciences will receive $2.6 million from CARB-X to develop CMTX-301, a vaccine designed to prevent bacterial biofilm formation.
The guidelines recommend a 4-month drug regimen for adults and children with drug-susceptible TB, and a 6-month regimen for those with drug-resistant TB.
Researchers also find that patients with penicillin allergy labels are more likely to get broad-spectrum antibiotics and have a higher risk of resistant infections and adverse events.
A review and meta-analysis of data from 28 countries found significant increases in resistance to clarithromycin, metronidazole, and amoxicillin from 2020 to 2023.
Among community-dwelling older adults in Ontario, longer outpatient antibiotic courses were not associated with a greater risk of harm or than shorter courses.
In more than 8,000 UK pneumonia patients, researchers found no evidence adjunctive macrolides lowered 30-day mortality or shortened time to hospital discharge.
The multivalent toxoid vaccine candidate from LimmaTech Biologics AG is designed to prevent skin and soft-tissue infections caused by Staphylococcus aureus.
In patients with Enterobacterales BSIs, early phenotype-desirable antimicrobial therapy was associated with better 30-day outcomes than delayed therapy.
The case was identified in a nursing home patient in North Carolina, but no transmission was detected.
Differences were driven by improved response rates for patients with pneumonia who were treated with ceftolozane–tazobactam.
At six Veterans Affairs clinics, quarterly antibiotic use reports and adverse event letters were associated with lower antibiotic prescribing.
Researchers say the findings raise concerns about antibiotic resistance from inappropriate use of broad-spectrum antibiotics.
Use of antibiotics in broiler chickens in the hatchery dropped from 90% in 2013 to less than 1% in 2023.
The strain of XDR Shigella sonnei, found in 3 men, is distinct from other globally circulating strains.
Researchers suggest the decline was linked to countries implementing movement restrictions, which resulted in fewer medical consultations.
Only 15% of responding pediatricians reported obtaining training on antibiotic use and antimicrobial resistance, and only 25% said they were aware of antimicrobial stewardship.
A review and meta-analysis of 56 randomized controlled trials found reductions of 11% to 23% across four antibiotic prescribing outcomes.
But the risk of bacterial infections in COVID-19 patients was substantially elevated after 48 hours compared with the other viruses.
Use of audit and feedback reports at 2 children's hospitals was associated with a 32% increase in the rate of appropriate antibiotic choice and duration for community-acquired pneumonia.
The odds of receiving first-line antibiotic therapy at pediatric urgent care centers were lower in White children and those with commercial insurance.
A population-wide cohort study in Ontario finds that more than 15% of residents colonized with resistant bacteria went on to develop an infection with the same organism.
The partnership will evaluate the clinical need and address market barriers for diagnostic, therapeutic, and preventive interventions for gonorrhea in low-resource countries.
Researchers found that more than two thirds of patients with negative chest x-rays received antibiotics.
