Danish research and development company GlyProVac will receive $467,000 to develop a maternal vaccine that targets a leading cause of neonatal sepsis.
Data on Salmonella and Campylobacter bacteria from people and food-producing animals show high levels of resistance to commonly used antibiotics.
Of the 135 isolates, 55% were identified as containing multi-drug resistant E coli.
At least 10 people have been sickened by E coli in an outbreak tied to raw milk cheese, and a Salmonella outbreak linked to charcuterie meats has grown to 70 cases.
With the pipeline for new antibiotics weak and underfunded, vaccines are seen as a potential tool for preventing the infections that drive antibiotic use and resistance.
The experimental vaccine is currently being evaluated in a phase 3 clinical trial in patients aged 60 years and older.
The study found that E coli from people and meat products sold at markets in Cambodia contained resistance genes and mobile resistance elements that were strikingly similar.
The vast majority of patients had community-onset invasive E coli (94%) and required hospitalization (97%), with 32% of patients needing ICU treatment.
Using long-read sequencing, the group found that 15% of E coli O157:H7 fecal samples harbored AMR genes.
Patient interviews suggest ground beef bought from the same grocery chain, and an investigation into the source is underway.