Among more than 124,000 US sepsis patients who had no resistant organisms through day 4 of hospitalization, antibiotics were de-escalated in less than 30%.
The study found that viruses and tropical diseases were more significant causes of sepsis in India than previously known.
A review and meta-analysis found that the pooled prevalence of carbapenem resistance in bacteria from newborns with suspected sepsis in Africa was 30.4%.
The new test can cut the time to treatment from 2 or 3 days to about 13 hours, the authors say.
Patients with suspected community-onset sepsis accounted for half of total inpatient antipseudomonal beta-lactam antibiotic and anti–MRSA antibiotic days.
The two studies indicate that continuous infusions of beta-lactam antibiotics reduce the risk of mortality in critically ill sepsis patients.
Administering antibiotics more than 5.5 hours after emergency department arrival was associated with increased odds of 3- and 30-day mortality.
Researchers found in-hospital mortality was higher at safety-net hospitals than non–safety-net hospitals, but 30-day mortality was similar.
The maternal vaccine will target neonatal sepsis caused by Klebsiella pneumononiae.
In patients with suspected sepsis, the use of piperacillin-tazobactam was associated with a 5% increase in 90-day mortality compared with cefepime.
