The results of a phase 4 randomized controlled trial indicate shortened regimens of preventive tuberculosis (TB) therapy are safe and effective options for preventing active TB infections, US and Brazilian researchers reported yesterday in PLOS Medicine.

The trial, conducted in Rio de Janeiro and Manaus, assigned 500 people age 15 and older without HIV who had household or occupational exposure to individuals with confirmed TB infection to receive either one or three months of isoniazid and rifapentine (HP; 1HP or 3HP). 

Both regimens have been found in previous trials to be effective at preventing active TB infection and are significantly shorter than the standard regimen (six to nine months of isoniazid), which has been the mainstay of TB preventive therapy (TPT) for decades but has had "abysmal" uptake and poor completion rates. But some data gaps remain.

"The availability of two innovative short-course TPT regimens offers a transformative opportunity for global tuberculosis control and achieving the End TB targets," the study authors wrote. "However, the safety of the 1HP regimen in people without HIV infection has not been thoroughly evaluated, and the relative acceptability of 1HP versus 3HP is unknown."

High completion rates in both groups

The primary outcomes of the trial were successful completion of more than 90% of medication in the regimens and safety.

Both treatment regimens had high completion rates—89.6% in 1HP recipients and 84.1% in the 3HP group. Adverse reactions were mostly mild or moderate, with targeted safety events or treatment discontinuation because of side effects occurring in 16.1% of patients in the 1HP group and 10.4% in the 3HP arm. Neither regimen was considered superior to the other.

The study authors say the results provide clinicians, public health officials, and patients with the data needed to make informed choices about which regimens to use and could help Brazil and other high TB-burden countries achieve TB control. 

“Preventing TB with short courses of well-tolerated medicines ensures that millions more people around the world can be protected from the devastating consequences of TB disease,” coauthor Marcelo Cordeiro-Santos, MD, PhD, said in a journal press release.

Mexican health officials are reporting six new human cases of myiasis caused by New World screwworm (NWS) over the past week.

In an epidemiologic surveillance report released earlier this week, Mexico's Ministry of Health said 141 cases have now been reported from eight Mexican states, up from 135 the previous week. Most of the cases (103) of the parasitic infection, which is carried by the Cochliomyia hominivorax fly, have been in Chiapas. Mexico has also reported more than 600 cases in animals.

The infection occurs when the flies deposit eggs into the open wounds and mucous membranes of warm-blooded animals; the eggs develop into larvae that burrow into the flesh, causing severe damage. Cases can be fatal if left untreated. 

Sterile fly dispersal facility opens

While human cases are rare, US officials have been concerned about the northward spread of NWS from Central America and the potential threat to the US cattle industry. 

In May 2025, the US Department of Agriculture (USDA) suspended livestock imports at the southern border because of an increase in cattle infections in Mexico. The following month, USDA Secretary Brooke Rollins announced the agency would launch a sterile fly dispersal facility in Edinburg, Texas, near the Mexican border. 

Releasing sterile male flies outside of affected areas ensure that female NWS flies, which only mate once, will encounter only sterile partners and not be able to reproduce.

The USDA announced the completion of the facility earlier this week.

"This new facility is a monumental achievement for our domestic preparedness efforts, but we are also diligently working to stop the spread of screwworm in Mexico, conduct extensive trapping and surveillance along the border, increase U.S. response capacity, and encourage innovative solutions," Rollins said in a press release.

The Trump administration is moving to rescind $600 million in federal health funding in four Democrat-led states—California, Colorado, Illinois, and Minnesota—with potentially far-reaching consequences for infectious-disease prevention, including HIV and other sexually transmitted disease (STD), according to media reports. 

“Reports that the Administration intends to slash hundreds of millions of dollars in Centers for Disease Control and Prevention [CDC] funding, including programs supporting HIV and STD prevention and HIV surveillance, are deeply troubling,” Anna K. Person, MD, chair of the HIV Medicine Association said in a press release emailed to reporters. 

Person notes that many grants under scrutiny expand access to HIV pre-exposure prophylaxis, “one of the most effective tools we have to prevent HIV and a strategy the Administration itself has identified as central to ending the HIV epidemic.”

Some of the funds, which Congress had already appropriated for use by state and local public health departments, are earmarked for programs that support the needs of specific communities, such as HIV prevention among Black women and Latino and African American men men who have sex with men. Last fall, the CDC revised its stated priorities, including a shift away from diseases that affect specific populations.  

Minnesota officials not yet notified of cuts

In Minnesota, officials said they have not yet received formal notice about specific funding changes.

“The Minnesota Department of Health (MDH) has yet to receive any direct communication this week from the federal government on the status of grant funding,” said Andrea Ahneman, MA, MPH, spokesperson for the MDH. “We are certainly concerned about the impact that potential cuts to federal funding could have on the health of Minnesotans and the state’s public health infrastructure.” 

Person urged the administration to withdraw the proposed rescissions and called on Congress to protect programs vital to disease prevention, adding that “the health of our communities depends on it.”