Clostridium difficile

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Stewardship / Resistance Scan for Jan 24, 2020

BARDA boosts funding for development of new C difficile antibiotic

Summit Therapeutics yesterday announced that the Biomedical Advanced Research and Development Authority (BARDA) has awarded the company an additional $8.8 million for clinical and regulatory development of an investigational antibiotic for treating Clostridiodes difficile infection (CDI).

  • BARDA funding for new C diff drug
  • Investing to tackle antibiotic resistance

Stewardship / Resistance Scan for Jan 22, 2020

Pets may be protective against recurrent C difficile, study finds

In a surprising finding, pet ownership and increasing contact with pets may be protective against the recurrence of community-acquired Clostridiodes difficile infection (CDI), researchers from the University of Pennsylvania reported recently in Open Forum Infectious Diseases.

  • Pets and C diff protection
  • C diff antibiotic exposure risk

Stewardship / Resistance Scan for Jan 13, 2020

CARB-X awards $3.2 million for monoclonal antibody against superbugs

CARB-X today said it has awarded Trellis Bioscience of Redwood City, California, up to $3.2 million to develop an innovative monoclonal antibody designed to disrupt the protective biofilm that makes bacteria resistant to antibiotics.

  • Monoclonal antibodies for superbugs
  • ID consult and death, prescribing
  • C diff carriage and farm living

Stewardship / Resistance Scan for Jan 06, 2020

Review: Pediatric stewardship programs have impact, but mainly in US

A systematic review of 113 studies indicates that pediatric antimicrobial stewardship programs (ASPs) have a significant impact on the reduction of targeted and empiric antibiotic use, costs, and antimicrobial resistance in both inpatient and outpatient settings, researchers reported late last week in Antimicrobial Resistance and Infection Control.

  • Pediatric stewardship review
  • Carbapenem resistance in Egyptian hospitals
  • Targeted C diff reduction

Stewardship / Resistance Scan for Jan 03, 2020

Survey of European ICU docs finds concern over multidrug resistance

More than half of physicians in European intensive care units (ICUs) say multidrug-resistant (MDR) infections are a problem in their hospitals, according to a survey published yesterday in Antimicrobial Resistance and Infection Control.

  • Antibiotic resistance in European ICUs
  • C diff carriers and hospital contamination

Stewardship / Resistance Scan for Dec 30, 2019

New clindamycin-resistant C difficile strain identified in VA patients

A surveillance study of patients in a Veterans Administration (VA) long-term care facility and its affiliated acute care hospital detected the clonal outbreak of a newly recognized Clostridioides difficile strain, researchers reported yesterday in Emerging Infectious Diseases.

  • Clindamycin-resistant C diff
  • Fluoroquinolones for bloodstream infections

Stewardship / Resistance Scan for Dec 13, 2019

UK study supports whole-genome sequencing for resistance surveillance

New research by a team of scientists from the United Kingdom suggests that whole-genome sequencing (WGS) should be considered as an alternative to traditional phenotypic testing for national surveillance of antibiotic resistance.

  • Whole-genome sequencing for surveillance
  • Asymptomatic C diff carriers

Stewardship / Resistance Scan for Dec 06, 2019

Study: Mandatory surveillance of priority pathogens lacking in Europe

A review of national documents shows that fewer than half of European countries have implemented publicly accessible mandatory surveillance of at least one of the World Health Organization's (WHO's) priority pathogens, European researchers reported yesterday in Clinical Microbiology and Infection.

  • European priority pathogen surveillance
  • US hospital stewardship

Stewardship / Resistance Scan for Nov 27, 2019

Scientists develop genotype-phenotype rapid susceptibility test

Scientists from Harvard University and the Massachusetts Institute of Technology report that a diagnostic test they developed allows simultaneous detection of genotype and phenotype, enabling rapid and accurate antibiotic susceptibility determination in under 4 hours, according to their findings detailed in a letter in Nature Medicine.

  • Rapid susceptibility test
  • Vegetarians harboring superbugs
  • Fidaxomicin against C diff in kids

Stewardship / Resistance Scan for Nov 11, 2019

Study shows decline in C difficile incidence at VA hospitals

A retrospective analysis of Veterans Administration (VA) patients who had stool testing for Clostridiodes difficile shows an overall decrease in C difficile infection (CDI) over the course of a decade, with temporal increases linked to implementation of molecular testing methods, researchers reported today in Infection Control and Hospital Epidemiology.

  • C diff in VA hospitals
  • UK antibiotic development
  • ESBL carriage in dogs

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