Clostridium difficile

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Stewardship / Resistance Scan for May 23, 2018

NDM, MCR-1 resistance genes found in same E coli isolates in China

Chinese scientists yesterday reported on the emergence of extensively drug-resistant (XDR) Escherichia coli carrying both New Delhi metallo-beta-lactamase (NDM) and MCR-1 genes in chickens at slaughter in China and detailed the features of two novel NDM-carrying plasmids.

  • NDM plus MCR-1 in E coli
  • C diff and sharps containers

Stewardship / Resistance Scan for Apr 26, 2018

Study: Mass distribution of azithromycin reduces childhood mortality in Africa

A study today in the New England Journal of Medicine reports that childhood mortality in sub-Saharan African communities randomly assigned to mass distribution of azithromycin was lower than in those assigned a placebo. But the authors warn that resistance emerging from mass distribution of the antibiotic could curb or reverse any potential benefit.

  • Mass distribution of azithromycin
  • Probiotics and CDI
  • New CARB-X funding

Stewardship / Resistance Scan for Apr 12, 2018

Study finds overreporting of healthcare-associated C diff in urban hospital

A study yesterday in the American Journal of Infection Control has found that only 62% of reported cases of healthcare facility–onset Clostridium difficile (HO-CDI) at a New York hospital met clinical criteria.

  • Overreporting C difficile
  • MCR-1 in travelers
  • Drivers of irrational antibiotic use

Stewardship / Resistance Scan for Apr 04, 2018

Defensive medicine found common when prescribing antibiotics

A study group with the European Society of Clinical Microbiology and Infectious Diseases (ESCMID) reports that 45% of specialists in infectious diseases and clinical microbiology sometimes worried and 29% often worried about malpractice implications when prescribing or advising on antibiotic prescriptions, and 85% reported defensive behaviors when prescribing, according to a study today in the Journal of Antimicrobial Ch

  • Defensive prescribing
  • C diff drop with diagnostic stewardship
  • AMR levels in Cambodian kids

Stewardship / Resistance Scan for Mar 29, 2018

Candida auris cases in Europe on the rise, with 620 since 2013

From 2013 through 2017 European officials recorded 620 cases of Candida auris, mostly from four large outbreaks, and 110 of them (17.7%) involved bloodstream infections, according to a report today in Eurosurveillance.

  • Candida auris in Europe
  • Experimental C diff drug

Stewardship / Resistance Scan for Mar 26, 2018

Survey finds audit and feedback key to antibiotic stewardship success

A survey of 244 members of three infectious diseases societies reveals that the most common approached to antimicrobial stewardship programs (ASPs) are antibiotic reviews with prospective audit and feedback (PAF), prior authorization for select antibiotics, and guideline development, according to a study today in Clinical Infectious Diseases.

  • Cornerstones of stewardship
  • Resistant Acinetobacter in kids
  • C diff prediction tool
  • Perceived AMR risk in Germany

Stewardship / Resistance Scan for Mar 20, 2018

TB incidence falling in Europe, but drug-resistant cases rising

A new surveillance report from the European Centre for Disease Prevention and Control (ECDC) shows that the tuberculosis (TB) incidence rate in Europe is declining by an average of 4.3% a year, the fastest decline in the world compared with other regions. But officials warn that it's not falling fast enough to achieve the World Health Organization (WHO) goal of TB elimination in Europe by 2050.

  • Resistant TB in Europe
  • Appropriate C diff testing
  • Fast sepsis detection

Stewardship / Resistance Scan for Mar 07, 2018

Italian study finds large reservoir of MDR bacteria in nursing homes

Researchers in Italy report widespread diffusion of multidrug-resistant (MDR) bacteria in residents from long-term care facilities (LTCFs) in three different northern Italian regions, according to a study yesterday in Antimicrobial Resistance and Infection Control.

  • MDR bacteria in Italy
  • Guidance on C diff prevention

Stewardship / Resistance Scan for Mar 02, 2018

Survey finds low use of antibiograms among medical residents

A survey of medical residents found that 28% to 51% could not accurately identify pathogens to target with empiric therapy or select therapy with an appropriate spectrum of activity, and only 12% of respondents identified antibiograms as a prescribing resource, according to a study yesterday in Infection Control & Hospital Epidemiology.

  • Resident prescribing savvy
  • Monitoring animal antibiotics
  • C diff treatment failure predictors

Stewardship / Resistance Scan for Feb 22, 2018

Study evaluates cost-effectiveness of Clostridium difficile treatments

A systematic review of treatments for Clostridium difficile infection (CDI) yesterday in Infection Control and Hospital Epidemiology concludes that the most cost-effective treatment remains unclear.

  • Cost-effective C diff treatment
  • Latent TB guidelines

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