The study's safety board recommended halting enrollment after an assessment showed the chance was less than 1% that the study would demonstrate efficacy if completed.
The test the US Centers for Disease Control and Prevention uses to identify clade I mpox cases is 'most likely not reliable' for detection of the substrain identified in the study, the authors say.
Another mpox study today showed that dose-sparing vaccine administration of the Jynneos vaccine appeared to have worked.
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The serial interval was 8.7 days in 2022 and 14.2 days in previous years.
Of 371 patients hospitalized over an 8-month period in Kamituga health zone, 88% had recently visited bars for professional sexual interactions.
Officials also urged health providers to watch for possible clade 1 cases in people with travel history or epidemiological connections to African outbreak locations.
Ten countries reported case rises in March, with the Republic of Congo reporting the largest rise in Africa.
Five studies reported 2-dose protection ranging from 66% to 90%.
Many of the problems in the mpox response were due to a deflated and exhausted public health workforce across the country.
Despite the risk of severe infection from COVID-19, the study authors found that only 40.5% of residents were up to date with COVID vaccination.
Most infections occurred at lower latitudes from January to July (not including April) but were seen mainly at higher latitudes from August to December.
With the H5N1 avian flu virus now reported in 5 Michigan dairy herds, officials remind residents to avoid drinking unpasteurized milk.
Researchers said the new lineage may have been present in a local animal reservoir and that sustained spread is a concern for the DRC and other world regions.
