The Coalition for Epidemic Preparedness Innovations (CEPI) announced earlier today that the University of Oxford has entered a licensing arrangement with the Serum Institute of India (SII) to create the largest-ever reserve of an investigational Rift Valley fever vaccine ready for testing.
Under the agreement, CEPI said, SII will manufacture up to 100,000 doses of Oxford’s investigational vaccine candidate, ChAdOx1 RVF. The first 10,000 doses will be used in a potential upcoming clinical trial assessing the safety and immunogenicity of the vaccine candidate in outbreak-affected areas.
COVID-19 powerfully showed us that we need to get ahead of fast-spreading viruses before they get ahead of us.
“COVID-19 powerfully showed us that we need to get ahead of fast-spreading viruses before they get ahead of us. This collaboration embodies that principle. Two of the world’s most distinguished vaccine institutes have worked together to mobilise and manufacture thousands of doses of a Rift Valley fever’s vaccine candidate in a matter of weeks,” said CEPI CEO Richard Hatchett, MD.
Rift Valley fever is a mosquito-borne disease that primarily affects livestock. Humans can contract the virus, however, and infections can be fatal, with some cases leading to brain inflammation and severe bleeding.
Senegal and Mauritania have seen an ongoing outbreak of the virus, with 610 cases and 42 deaths as of December 2025.