Quality improvement linked to better antibiotics for kids' skin infections
A quality-improvement (QI) program implemented at a children's healthcare system in Georgia was associated with improved antibiotic selection and duration for children with skin infections, researchers reported today in Pediatrics.
The QI program, implemented in three emergency departments (EDs) and eight urgent care centers (UCs) within Children's Healthcare of Atlanta, aimed to optimize outpatient antibiotic selection and duration for uncomplicated skin/soft tissue infections (SSTIs). Optimal treatment was defined as 5 days of cephalexin for nonpurulent (not containing pus) SSTIs and 7 days of clindamycin or trimethoprim/sulfamethoxazole for purulent SSTIs.
Interventions included revised SSTI treatment guidelines, provider education, a discharge order set, and participation in a maintenance of certification (MOC) QI project that involved education sessions, monthly group feedback, and individual scorecards. The MOC QI project included 50 ED and UC physicians (27% of eligible physicians).
To evaluate the success of the program, researchers compared antibiotic prescribing data for SSTIs during the baseline period (January 2018 to June 2019) and the postintervention phase (July 2019 to March 2021).
A total of 9,306 SSTIs were included, with 5,507 ED visits (59.2%) and 3,799 UC visits (40.8%). For all providers (MOC and non-MOC participants), optimal antibiotic choice plus duration for purulent SSTIs increased from 28% at baseline to 64%. For nonpurulent SSTIs, optimal antibiotic choice plus duration increased from 2% to 43%.
MOC participants had a similar baseline performance but showed greater improvement in optimal antibiotic prescribing for purulent (84%) and nonpurulent SSTIs (68%). Return visits requiring escalation of care did not significantly change pre- to post-intervention.
The study authors suggest the greater improvement among MOC participants may have been driven by monthly scorecards with individual performance.
"Although other QI projects have focused on inpatient management of SSTIs, this multisetting QI project focused on evidence-based outpatient antibiotic prescribing for pediatric SSTIs," the study authors wrote. "Our results could be readily generalized to other large, tertiary pediatric care centers looking to implement QI initiatives surrounding outpatient antibiotic stewardship."
Sep 8 Pediatrics abstract
Multidrug-resistant Shigella outbreak in Spain tied to cases in Belgium, UK
A study published this week in JAC-Antimicrobial Resistance confirms that a strain of multidrug-resistant (MDR) Shigella sonnei found in men who have sex with men (MSM) in Spain is similar to strains found elsewhere in Europe.
In the study, researchers from Seville, Spain, conducted genomic and molecular analysis of isolates from seven patients with shigellosis caused by MDR S sonnei that had similar epidemiologic characteristics. The cases were reported at a university hospital in Seville from October to December 2021, and of the six patients who reported sexual history, four identified as MSM.
All isolates showed resistance to penicillins, cephalosporins, fluoroquinolones, cotrimoxazole, and azithromycin, and whole-genome sequencing identified several resistance determinants, including azithromycin resistance genes and the blaCTX-M-27 gene, which carries an extended-spectrum beta-lactamase (ESBL) enzyme.
Further analysis found that all of isolates belonged to the same outbreak strain and were closely related to isolates from recent outbreaks of extensively drug-resistant (XDR) S sonnei in MSM in Belgium and the United Kingdom.
"Our results suggest that we are dealing with a high-risk clone of S. sonnei in continuous evolution," the study authors wrote. "The differences in terms of plasmid structures as well as the number of plasmids harboured by the seven S. sonnei isolates seems to indicate that this outbreak was produced by the transmission of one clone that is able to evolve and disseminate rapidly."
A report in February from the European Centre for Disease Prevention and Control noted an increase in XDR S sonnei infections in the United Kingdom and elsewhere in Europe and warned that the risk of spread among networks of MSM who engage in high-risk sexual practices, such as oral-anal contact, could be high in the coming months.
The authors say tracking the spread of successful epidemic clones of MDR S sonnei and understanding their evolution will be important for monitoring and control of outbreaks.
Sep 5 JAC-Antimicrob Resist study