Investigators with the endTB trial say the 9-month, all-oral drug regimens will make it easier for patients with rifampicin-resistant TB to complete the full treatment.
Sixty-seven active TB cases and 79 latent TB cases have been reported in 2 Kansas counties since the beginning of 2024.
With a total of $100 billion spent, PEPFAR is the largest public health commitment in history by any country to address a single disease.
Genomic analysis identified strains of multidrug-resistant TB with additional resistance to the 6-month BPaL/M treatment regimen.
The guidelines recommend a 4-month drug regimen for adults and children with drug-susceptible TB, and a 6-month regimen for those with drug-resistant TB.
A meta-analysis of data from two trials found 6 months of levofloxacin in kids and adults exposed to MDR-TB was associated with a 60% relative reduction in TB incidence.
The Xpert MTB/RIF Ultra test is the first TB diagnosis test to meet the WHO's prequalification standards.
Researchers find that 10% of children living in an area of high TB transmission developed TB disease by the age of 10.
The report also spotlights the urgency of vaccines for pathogens such as group A Streptococcus and Klebsiella pneumoniae, which are increasingly resistant to antimicrobials.
WHO data show 8.2 million people were newly diagnosed with TB in 2023, up from 7.5 million in 2022 and the highest number recorded since 1995.
