A study by Mayo Clinic researchers found a high prevalence of antibiotic use among hospital-at-home (HaH) patients. The findings were published today in Infection Control & Hospital Epidemiology.
For the retrospective study, the researchers analyzed use of antimicrobials (antibiotics, antifungals, and antivirals) in Mayo Clinic's Advanced Care at Home program, which provides inpatient home care for patients in Arizona, Florida, and northwestern Wisconsin, from January 2023 through December 2024.
Among the benefits of HaH compared with traditional hospitalization are reduced healthcare costs, reduced hospital readmissions, and improved quality of life. The researchers note that while infections are a common HaH admitting diagnosis, HaH antimicrobial use in the United States has not been well characterized.
Over the study period, 2,398 (79.6%) of 3,012 adult HaH patients received a systemic antimicrobial, with antibiotics accounting for 585.6 days of therapy (DOT) per 1,000 days-present and antivirals and antifungals contributing 56.9 DOT and 29.4 DOT per 1,000 days-present, respectively. Three quarters (74.6%) of HaH patients received at least one antibiotic, 10.6% received an antiviral, and 4.7% received an antifungal. The monthly proportion of patients receiving an antibiotic increased by 0.18% per month, while antifungal use decreased by 0.05% per month. There was no significant change in antiviral use.
Integrating [antimicrobial stewardship] will be essential to optimize patient outcomes, reduce the burden of antimicrobial resistance, and ensure the sustainability of this innovative care model.
Respiratory viruses were the most prevalent indication for antibiotic use (33.9% of all patients receiving an antibiotic), followed by urinary tract infections (30.5%). Ceftriaxone was the most frequently administered antibiotic (32.7% of patients), followed by cefepime (15.4%) and piperacillin-tazobactam (12.5%). Among patients who received an antibiotic, 89.6% were administered at least one intravenous dose.
Opportunities for stewardship
The study authors say the high prevalence of antibiotic use observed in the study warrants further investigation into antimicrobial stewardship (AMS) opportunities in HaH settings.
"As HaH programs continue to expand, integrating AMS will be essential to optimize patient outcomes, reduce the burden of antimicrobial resistance, and ensure the sustainability of this innovative care model," the study authors wrote.