WHO report on Chinese H7N9 cases notes possible human-to-human spread in cluster
After five human cases of avian influenza A (H7N9) appeared in China earlier this month, the World Health Organization (WHO) has said that limited human-to-human transmission cannot be ruled out for some that are part of a family cluster. Three of the five recent cases in humans appear to be in a cluster, the WHO said today in a statement.
Two of the five cases had direct exposure to poultry, but there were no reports of direct exposure in the other three cases. The WHO said the three patients with no exposure to poultry were family members.
"Investigations are on-going, at this stage human-to human-transmission cannot be ruled out, however to date no further transmission has been reported," the WHO said in a statement today.
According to Hong Kong's Centre for Health Protection (CHP), China's agriculture ministry reported positive poultry market samples from 10 of China's provinces between January 2015 and May 2016. H7N9 is now enzootic on China’s mainland. The five cases raise the global H7N9 cases to 807, according to FluTrackers, an infectious disease news message board.
Aug 17 WHO statement
Aug 12 CIDRAP News scan
FluTrackers H7N9 case list
H5N6 isolated from China poultry market air sample
A sample collected during bioaerosol surveillance at three live poultry markets in Zhongshan, a city in China's southern Guangdong province, yielded the H5N6 avian influenza strain, the first report of a viable virus from the strain from an air sample. Chinese researchers reported their findings in an Aug 9 letter to the Journal of Infectious Diseases.
Of 243 air samples collected, 19 were initially positive for influenza A RNA. One sample that was inoculated in chicken eggs yielded H5N6, based on reverse-transcriptase polymerase chain reaction (RT-PCR) testing and genome sequencing. Sequencing showed that the virus was similar to other recent H5N6 strains in poultry, with some gene segments that were similar to H5N6 strains that have infected humans.
The teams said the findings suggest that the strain they found could be transmitted from poultry to humans through the airborne route and that if aerosol transmission is confirmed, it would add to the complex ecology of influenza A. They also said biosafety measures for those with occupational exposure to poultry should be reexamined and that more study is needed on airborne avian influenza viruses in live poultry markets.
The first human infection involving the novel virus was reported by China in 2014, and the country has now reported 15 such cases. China and a few other Asian countries have reported H5N6 in poultry, but China is the only country to report human cases.
Aug 9 J Infect Dis letter