News Scan for Dec 16, 2015

Saudi MERS case
More MCR-1 found
Vaccine-derived polio in Laos

MERS infects another healthcare worker in Saudi Arabia

Saudi Arabia's Ministry of Health (MOH) today reported a MERS-CoV case, the country's first in 15 days. The case, from Buraidah, is likely linked to another recent case from the same location. The latest patient is a healthcare worker who contracted the virus in a healthcare setting.

The MOH also said the latest case-patient is a 41-year-old foreign woman who is symptomatic and in stable condition. The earlier Buraidah case, reported Nov 29, was considered primary.

Buraidah is in north central Saudi Arabia, about 220 miles northwest of Riyadh.

The new case lifts the country's total from MERS-CoV (Middle East respiratory syndrome coronavirus) to 1,280 cases, 550 of them fatal.
Dec 16 Saudi MOH statement


Colistin-resistance gene MCR-1 noted in UK, another Danish patient

MCR-1, the recently identified gene that disables the last-line antibiotic colistin, has now been identified in the United Kingdom and in another patient in Denmark, according to a post yesterday on Germination, a National Geographic public health, food, and disease blog.

The gene was first identified in China, as noted in The Lancet Infectious Diseases on Nov 18, then noted in Malaysia and Portugal. On Dec 3 Danish scientists reported it one patient and in five samples of imported poultry meat.

In the latest developments, Public Health England announced it found MCR-1 in 15 stored bacterial samples from 2012 to 2015: 10 Salmonella samples and 3 Escherichia coli samples from hospitalized patients, as well as 2 Salmonella samples from imported poultry meat. In addition, the Danish researchers who reported their country's first findings told Germination author Maryn McKenna that the resistance factor has been identified in an additional patient, from 2011.

The Lancet Infectious Diseases today tweeted that it will report new developments about the gene sometime later this week.
Dec 15 Germination blog post
Nov 20 CIDRAP News scan on first MCR-1 report
Dec 4 CIDRAP News scan on findings in Denmark
Lancet Infect Dis Twitter feed


Two cases of vaccine-derived polio reported in Laos

Laos has confirmed two new cases of vaccine-derived poliovirus-1 (VDPV1) cases, bringing the country's recent total to five, the World Health Organization (WHO) reported yesterday.

The cases involve 7-month-old and 14-month old boys in Xaisomboun province, which had not previously reported any VDPV1 cases. The younger child first experienced paralysis on Oct 3 after receiving oral polio vaccine (OPV) on Sep 30. Stool samples from two of his contacts tested positive for VDPV1 on Nov 4.

The older boy had fever onset on Oct 26 and his first paralysis symptoms on Oct 28. He also had received OPV. Two of three close contacts tested positive for the virus on Nov 4.

In addition to the five polio cases, the first of which was reported Oct 12, 16 health contacts in Bolikhamxay and Xaisomboun provinces have tested positive for VDPV1 via stool sample since the beginning of the outbreak, the WHO said.
Dec 15 WHO statement
Oct 12 CIDRAP News scan on first case

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