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New Asian clinical trial network aims to tackle resistant infections

The National University of Singapore (NUS) has received a $1.8 million grant from the Wellcome Trust to establish a clinical trial network focused on antibiotic-resistant infections.

COVID-19 restrictions in Australia linked to lower community antibiotic use

COVID-19 restrictions in Australia were associated with a substantial decline in community dispensing of antibiotics for respiratory infections, researchers reported this week in the British Journal of Clinical Pharmacology.

Study finds antibiotics, other medications in urban streams

Screening of a network of urban streams in Baltimore revealed high concentrations of pharmaceuticals, including antibiotics, researchers reported this week in Environmental Science & Technology.

Our weekly wrap-up of antimicrobial stewardship & antimicrobial resistance scans

Study finds antibiotics, other medications in urban streams

Screening of a network of urban streams in Baltimore revealed high concentrations of pharmaceuticals, including antibiotics, researchers reported this week in Environmental Science & Technology.

Procalcitonin testing may reduce antibiotics for COVID pneumonia

Early use of a procalcitonin-guided algorithm in non-critically ill patients hospitalized with COVID-19 pneumonia reduced antimicrobial use with no adverse effects, researchers reported last week in JAC-Antimicrobial Resistance.

European data show big drop in antibiotic use during the pandemic

New data from the European Centre for Diseases Prevention and Control (ECDC) show a dramatic drop in community antibiotic use across Europe during the first year of the COVID-19 pandemic.

Our weekly wrap-up of antimicrobial stewardship & antimicrobial resistance scans

European data show big drop in antibiotic use during the pandemic

New data from the European Centre for Diseases Prevention and Control (ECDC) show a dramatic drop in community antibiotic use across Europe during the first year of the COVID-19 pandemic.

Antibiotic spectrum index could boost antibiotic stewardship in NICUs

Use of an antibiotic spectrum index (ASI) helped identify patterns of empiric antibiotic prescribing at three neonatal intensive care units (NICUs) and could help guide stewardship efforts, US researchers reported today in Infection Control & Hospital Epidemiology.

Study shows rising use of ceftazidime-avibactam for CRE infections

A large study of patients in Veterans Administration (VA) hospitals shows a significant increase in the use of ceftazidime-avibactam for carbapenem-resistant Enterobacterales (CRE) infections, US researchers reported today in Infection Control & Hospital Epidemiology.

Our weekly wrap-up of antimicrobial stewardship & antimicrobial resistance scans

Study shows rising use of ceftazidime-avibactam for CRE infections

Originally published by CIDRAP News Nov 24

Veterinary antimicrobial sales show significant decline in Europe

A new report from the European Medicines Agency (EMA) shows sales of veterinary antimicrobials have fallen by more than 40% since 2011.

Study ties long-haul COVID-19 with chronic fatigue, breathing problems

Many COVID-19 survivors experience impaired circulation, abnormal breathing patterns, and chronic fatigue syndrome an average of 9 months after diagnosis, finds a small, single-center study yesterday in JACC: Heart Failure.

Study suggests contact precautions for MRSA, VRE can be safely removed

A study conducted in 15 hospitals found that discontinuing contact precautions for methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus (VRE) did not result in increased healthcare-associated infection (HAI) rates, researchers reported today in Infection Control & Hospital Epidemiology.

USDA to study antimicrobial use, resistance on swine farms

The US Department of Agriculture's (USDA's) Animal and Plant Health Inspection Service (APHIS) announced this week that it has begun an effort to study antimicrobial use and resistance on commercial swine farms in the Midwest.

Paper highlights use of pre-adapted phage against a pan-resistant infection

A new paper in Nature Communications describes the use of a pre-adapted bacteriophage in combination with antibiotics to treat a patient with a fracture-related, pandrug-resistant (PDR) Klebsiella pneumoniae infection.

Phase 3 trial finds oral microbiome therapy cuts risk of recurrent C diff

In a phase 3 trial, an investigational oral microbiome therapy was superior to placebo in reducing the risk of recurrent Clostridioides difficile infection, researchers reported yesterday in the New England Journal of Medicine.

Our weekly wrap-up of antimicrobial stewardship & antimicrobial resistance scans

Phase 3 trial finds oral microbiome therapy cuts risk of recurrent C diff

In a phase 3 trial, an investigational oral microbiome therapy was superior to placebo in reducing the risk of recurrent Clostridioides difficile infection, researchers reported yesterday in the New England Journal of Medicine.

Study highlights non-guideline adherent antibiotic treatment for C diff

A review of Clostridioides difficile infection (CDI) treatments at 10 community hospitals found that only 50% of treatment regimens were adherent to guidelines regarding use of fidaxomicin, researchers reported today in Infection Control & Hospital Epidemiology.

Study suggests shorter IV antibiotic durations for young infants with UTIs

A review and meta-analysis of studies on urinary tract infections (UTIs) in young infants suggests shorter intravenous (IV) antibiotic courses, with an early switch to oral antibiotics, should be considered, Australian researchers reported yesterday in Pediatrics.

Similar immune response after same, different COVID-19 vaccine booster

Among 457 adult participants in an ongoing phase 1/2 clinical trial who completed primary COVID-19 vaccination with the Moderna, Johnson & Johnson (J&J), or Pfizer/BioNTech vaccines, a booster dose with either the same (homologous) or a different brand (heterologous) induced an immune response and was safe.

New EU rules on antibiotic use on farms take effect

New rules limiting the use of antibiotics in food-producing animals in the European Union went into effect today.

Our weekly wrap-up of antimicrobial stewardship & antimicrobial resistance scans

New EU rules on antibiotic use on farms take effect

New rules limiting the use of antibiotics in food-producing animals in the European Union went into effect today.

Stewardship bundle tied to better antibiotic prescribing for virtual visits

A multifaceted stewardship intervention aimed at virtual visits was tied to improvements in guideline-concordant antibiotic prescribing for upper respiratory tract infections (URTIs) and sinusitis, University of Michigan researchers reported today in Infection Control & Hospital Epidemiology.

New C difficile guidelines favor fidaxomicin over vancomycin

Guidelines published yesterday by the Infectious Diseases Society of America (IDSA) and the Society for Healthcare Epidemiology of America (SHEA) contain three new recommendations for treating adults who have Clostridioides difficile infection (CDI).

Our weekly wrap-up of antimicrobial stewardship & antimicrobial resistance scans

New C difficile guidelines favor fidaxomicin over vancomycin

Guidelines published yesterday by the Infectious Diseases Society of America (IDSA) and the Society for Healthcare Epidemiology of America (SHEA) contain three new recommendations for treating adults who have Clostridioides difficile infection (CDI).