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The death rate was high in patients with chronic kidney disease and in those who developed kidney injury in the ICU.
A randomized, controlled clinical trial involving high-risk healthcare workers found that pre-exposure prophylaxis with hydroxychloroquine once or twice weekly did not significantly reduce COVID-19 compared with placebo, researchers reported late last week in Clinical Infectious Diseases.
The comprehensive study is geared toward flagging countries that have a heavy chronic disease burden and thus are more vulnerable to a greater COVID impact.
In some states, like Wisconsin, hospitals are strained; also, Pfizer says its vaccine will be delayed.
As the next steps, officials will conduct a meta-analysis of remdesivir studies, which experts will use to guide treatment advice.
Our weekly wrap-up of antimicrobial stewardship & antimicrobial resistance scans
Originally published by CIDRAP News Oct 15
The emergency sick leave provision of the Mar 18 bipartisan Families First Coronavirus Response Act (FFCRA) appears to have reduced the spread of the virus. A Health Affairs study yesterday found that states where workers could get up to 2 weeks of paid sick leave showed 417 fewer confirmed cases per day, or an average of 1 prevented case per day per 1,300 workers.
In addition, a large group of scientists signs on to the John Snow Memorandum to mobilize against the herd immunity response concept.
Also, the DRC has gone 15 days without any new cases, and the WHO appoints two people to chair an investigation into sexual abuse allegations in the previous DRC outbreak.
The University of Texas Health Science Center at Houston (UTHealth) announced yesterday that it has received an $11 million grant from the National Institute of Allergy and Infectious Diseases to conduct a 5-year study to better understand why some critically ill patients develop multidrug-resistant infections.
A study yesterday in Journal of School Choice found that US schools in poor districts with large non-white student populations are less likely to reopen fully for the 2020 to 2021 academic year.
In US developments, cases are rising in 36 states, including a large swath of the Midwest and Northeast.
Those who consulted government sources held more science-based beliefs about the pandemic.
Tuberculosis notifications in the hard-hit countries of India, Indonesia, and the Philippines have fallen 25% to 30% because of pandemic-related disruptions.
CARB-X announced today that it is awarding up to $2.62 million to Swiss biopharmaceutical company Polyphor AG to develop a new antibiotic to treat infections caused by Enterobacteriaceae, including carbapenem-resistant Enterobacteriaceae (CRE).
In one of the first large-scale studies of COVID-19 transmission in US childcare programs, no association was found between day care exposure and COVID-19 transmission risk for providers.
Both a vaccine trial and monoclonal antibody trial have been paused.
Two studies show the new antibiotic is safe and effective for difficult-to-treat MDR infections.
Only 2 of 101 newborns had positive COVID-19 test results, but they had no signs or symptoms.
A group led by the African Commission through the Africa Centres for Disease Control and Prevention (Africa CDC), yesterday launched the Africa Pathogen Genomics Initiative (Africa PGI), a $100 million, 4-year partnership to expand and integrate next-generation genomic sequencing (NGS) capabilities across the continent to improve health surveillance and lab networks and better tackle antimicrobial resistance (AMR).
