Nearly two thirds of antibiotics dispensed in community pharmacies around the world are given out without a prescription, according to a paper published yesterday in The Lancet Infectious Diseases.
The mixed-methods systematic review, conducted by a team of researchers from China, analyzed 162 studies on the dispensing of non-prescription antibiotics in community and retail pharmacies covering 52 countries. The pooled prevalence of community pharmacy non-prescription antibiotic dispensing was 63.4% (95% confidence interval [CI], 59.6% to 67.1%), with the highest prevalence seen in low-income nations (75.1%; 95% CI, 65.5% to 83.7%) and the lowest in high-income nations (48.4%; 95% CI, 40.5% to 56.4%).
Broken down by disease type, dispensing of non-prescription antibiotics was highest for urinary tract infections (71.2%; 95% CI, 58.4% to 82.5%), followed by upper respiratory tract infections (63.4%; 95% CI, 55.3% to 71.1%), diarrhea (60.3%; 95% CI, 51.5% to 68.7%), and bronchitis (48.0%; 95% CI, 12.1% to 85.1%). Additionally, non-prescriptions dispensing of antibiotics was more common in adults (70.8%; 95% CI, 64.3% to 76.9%) than children (52.2%; 95% CI, 43.2% to 61.1%).
The promotion of the appropriate use of antibiotics is a complicated process.
Quantitative studies indicated that pharmacies located in poorer economic areas, those staffed by pharmacy owners, and private pharmacies were more likely to dispense non-prescription antibiotics. Analysis of qualitative studies revealed four major factors driving dispensing of antibiotics without a prescription: strong customer demand for non-prescription antibiotics combined with a lack of relevant knowledge, pharmacy staff motivated by financial or personal viewpoints, expensive or inconvenient alternative healthcare services or irregular prescribing practices, and weak social, industry, and legal regulation.
The analysis also found that there has been no significant improvement in dispensing of non-prescription antibiotics at community pharmacies over the last 20 years, despite implementation of policies related to antibiotic sales in several countries.
"The promotion of the appropriate use of antibiotics is a complicated process," the study authors wrote. "A systematic approach, enhanced multisectoral cooperation, and mechanisms for cross-sectoral collaboration are needed."