A research letter yesterday in JAMA Network Open highlights the high perceived prevalence of US drug shortages and the negative outcomes related to patient care, primary care practice, and physician well-being.

The study was based on answers to a web-based survey conducted from July to August 2024 among primary care providers (PCPs) affected by drug shortages, with 902 participants included in the final analysis. 

Shortages cause workplace stress 

Overall, the perceived prevalence of drug shortages was high, at 88%, and participants said one in five patients had an outcome associated with drug shortages, such as pervasiveness, treatment changes and outcomes, and administrative burdens. The drug categories with the highest rate of severe outcomes were endocrinologic drugs (54%), stimulants (52%), and drugs for infectious diseases (26%).

Among the 87% of respondents who said drug shortages changed their quality of care, altering the drug of choice was more common (92%) than postponing prescribing (63%). PCPs said drug shortages resulted in more work for themselves and staff, especially in terms of prior-authorization paperwork. 

New care plan formulations caused by drug shortages are challenging for physicians.

“New care plan formulations caused by drug shortages are challenging for physicians, with multiple factors considered to ensure appropriate care alternatives and an increased staff workload with limited reimbursement,” the authors said. “This workplace stress caused most participants to feel frustrated by drug shortages.”

The Louisiana Department of Wildlife and Fisheries (LDWF) has announced the first case of chronic wasting disease (CWD) in a wild deer in Concordia Parish.

Concordia Parish is in east-central Louisiana, on the Mississippi River. The infected buck was taken by a hunter in the Richard K. Yancey Wildlife Management Area, LDWF said this week. The department said that it is implementing its CWD response plan. 

“We will continue to count on our hunters, property owners, deer processors and taxidermists for their assistance in monitoring CWD as their continued partnership with our department will help manage the expanse of CWD in the state keeping our deer population healthy,’’ LDWF Secretary Tyler Bosworth, JD, said in the news release.

Free CWD testing of hunter-harvested deer

Since CWD was first found in Louisiana in 2022, the state has tallied 49 positive cases. CWD is a neurodegenerative disease of cervids such as deer, moose, and elk. It spreads from animal to animal and via environmental contamination through infectious misfolded proteins called prions. It causes symptoms such as emaciation, excessive salivation and thirst, lack of coordination, loss of fear of humans, and eventually, death.

It is recommended that people hunting in areas known to harbor CWD-infected deer have their deer tested for the disease prior to consumption.

"Although CWD has not been shown to be contagious to humans, the Centers for Disease Control and the World Health Organization recommend against the human consumption of deer known to be infected with CWD,” LDWF said. 

“Also, it is recommended that people hunting in areas known to harbor CWD-infected deer have their deer tested for the disease prior to consumption,” it added. “LDWF provides CWD testing for hunter-harvested deer free of charge.”

• Today the Coalition for Epidemic Preparedness Innovations (CEPI) and the European Union’s Horizon Europe program announced $26.7 million in funding for new vaccine development of filoviruses, including Ebola virus, Sudan virus, Bundibugyo virus, and Marburg virus. A team at the University of Oxford will lead the research. There are two licensed vaccines for Ebola virus, but no vaccines are licensed for Sudan virus or Marburg virus. CEPI CEO Richard Hatchett, MD, said in a press release, “The first-ever outbreak of Marburg in Ethiopia is a stark reminder that filoviruses are among the world’s most menacing pathogens, capable of triggering devastating outbreaks and epidemics. A broadly protective filovirus vaccine could be transformative, protecting those most vulnerable to these viral threats and strengthening global health security against both known and emerging members of the filovirus family.”
• Virometix AG, a biotech company, today announced positive topline data from a phase 1 trial of V-212, a serotype-independent pneumococcal vaccine candidate, in development for the prevention of pneumococcal disease cause by Streptococcus pneumoniae infections. The vaccine candidate proved to be safe among 60 healthy volunteers aged 18 to 45 years, and the data showed evidence of a robust increase in immunoglobulin G antibodies.
• The nonprofit scientific research organization IAVI said earlier this week that the first doses of experimental HIV vaccine antigens had been administered as part of the IAVI G004 clinical trial in December at the Perinatal HIV Research Unit in Soweto, South Africa. Three antigens will be delivered via Modern’s mRNA platform, and the trial will assess safety, immune responses, and dose levels. “With this year’s global funding cuts to HIV prevention, care, and treatment, bringing new prevention tools forward is more important than ever. We believe we are on the most promising path ever pursued for the development of an effective vaccine against HIV,” said IAVI President and CEO Mark Feinberg, MD, PhD, in a press release.