Multiple risk factors linked to Candida auris infection after colonization

News brief

Candida auris illustration — Dr_Microbe / iStock

A study of hospital patients in Florida indicates that multiple comorbidities and invasive devices are significantly associated with progression from Candida auris colonization to infection, researchers reported last week in Clinical Infectious Diseases.

In one of the largest analyses of its kind, researchers from the Centers for Disease Control and Prevention and the Florida Department of Health used a case-control methodology to investigate factors associated with C auris infection after prior colonization among patients identified in Florida healthcare facilities from 2019 through 2023. An estimated 4,000 hospital patients in Florida have been colonized or infected with the multidrug-resistant yeast since it was first identified in the state in 2017, but why some patients develop clinical signs and symptoms while others remain colonized is unclear.

"Knowledge of the factors associated with progression to clinical infection can be used to improve facility testing protocols, healthcare provider knowledge, and infection prevention and control (IPC) measures to improve patient outcomes," the study authors wrote.

Age, low patient functional status among risk factors

After reviewing the records of 1,073 patients, the researchers identified 105 case-patients (median age, 64 years) with documented clinical specimens after colonization and 578 control subjects (median age, 69 years) with colonization only. Unadjusted measures revealed several factors that were significantly associated with progression to clinical cases, including the presence of five or more comorbid conditions (odds ratio [OR], 10.02; 95% confidence interval [CI], 4.07 to 24.7), four or more invasive devices (OR, 2.92; 95% CI, 1.70 to 5.03), or three or more recent medical procedures (OR, 2.32; 95% CI, 1.19–4.55).

Other factors included fully dependent care required for eating (OR, 2.80), limited mobility (OR, 2.15), inability to transfer (OR, 1.82), and being in the 50- to 64-year-old age-group (OR, 1.77).

The authors say healthcare facilities could consider prioritizing high-acuity patients for early C auris screening, transmission-based precautions, and infection prevention interventions.

"Further analysis to understand clinical implications and risk factors for C. auris progression after colonization is needed," they concluded. "Future efforts might include an adjusted analysis to more fully understand the risk that individual medical conditions and functional status have on C. auris clinical outcomes."

Cidara announces funding for non-vaccine flu preventive, CD388

News brief

Stephanie Soucheray, MA

Cidara Therapeutics, Inc announced it has received up to $339 million from the Biomedical Advanced Research and Development Authority (BARDA) to fund work on CD388, a non-vaccine preventive for both pandemic and seasonal flu.

"A long-acting, universal influenza preventative that confers broad protection against all strains of influenza across all populations is critical for pandemic preparedness, especially for the millions of Americans who are immune-compromised, have comorbidities that can lead to severe complications from influenza infection, or the elderly who have diminished response to vaccines," said Jeffrey Stein, PhD, Cidara president and CEO, in a press release. "We welcome BARDA's partnership that will enable us to accelerate domestic supply options for CD388 production."

CD388 not reliant on immune response

Cidara said the funding will help accelerate domestic supply options for CD388 production in the United States.

CD388 is an investigational drug-Fc conjugate (DFC). DFCs are not vaccines or monoclonal antibodies. Instead, the drugs are low-molecular-weight biologics designed to function as long-acting small molecule inhibitors. CD388 is being developed to offer season-long protection against multiple flu strains via a single subcutaneous or intramuscular administration.

Because CD388 is not a vaccine, its activity is not reliant on an immune response.

"Because CD388 is not a vaccine, its activity is not reliant on an immune response and thereby is expected to be efficacious in individuals regardless of immune status," Cidara said. In July the company presented data showing that the drug may protect adults from flu better than flu vaccines.

Permethrin-treated wraps cut malaria rates in babies by 66%

News brief

Mary Van Beusekom, MS

Woman with child in wrap on her back — Common Language Project / Flickr cc

The use of permethrin-treated cloth baby wraps among mothers of 6- to 18-month-old children in Uganda reduced clinical malaria infections in the babies by 66%, according to a study published in the New England Journal of Medicine.

Researchers at the University of North Carolina at Chapel Hill and the Mbarara University of Science and Technology in Uganda conducted a double-blind, randomized, controlled trial among women with a child aged 6 to 18 months old from June 2022 through April 2024 to determine if the insecticide lowered rates of the mosquito-borne illness.

The 400 mother–child pairs were randomly assigned in a 1:1 ratio to use permethrin-treated baby wraps (intervention group) or sham-treated wraps (control group). The wraps were retreated every 4 weeks, and all participants were given a new, pyrethroid-treated bed net.

Participants visited a trial clinic every 2 weeks for 24 weeks and made unscheduled visits if their child developed a fever. Clinical malaria was defined as fever and a positive malaria rapid diagnostic test.

"We leveraged the traditional practice of mothers carrying children on their backs in cloth wraps to assess whether treating the wraps with an insect repellent might provide a layer of protection against malaria," the study authors wrote. The wraps also serve as a blanket or swaddle when the children are set on the ground and in bed.

Integration with cultural norms

Clinic attendance was 99.9%. The incidence of clinical malaria was 0.73 cases per 100 person-weeks (95% confidence interval [CI], 0.51 to 1.02) in intervention recipients and 2.14 per 100 person-weeks (95% CI, 1.73 to 2.62) in controls (incidence rate ratio, 0.34), for a 66% reduction. Intervention recipients reported rash more often than controls (8.5% vs 6.0%).

We leveraged the traditional practice of mothers carrying children on their backs in cloth wraps to assess whether treating the wraps with an insect repellent might provide a layer of protection against malaria.

"Treatment of these wraps has potential advantages, including the ability to target young children (who are most vulnerable to the severe manifestations of malaria, including death), integration with existing cultural norms, protection against outdoor and daytime mosquito biting, and the minimization of direct contact with permethrin because the wrap is worn over clothing," the researchers concluded.