People with asthma in Hong Kong experienced worse control of their asthma after they had recovered from mild to moderate COVID-19, according to findings yesterday in Respiratory Research.
For the case-control study, researchers with the University of Hong Kong enrolled 111 people with asthma who had experienced mild to moderate COVID-19 from 30 to 270 days before enrollment and 110 asthma patients who hadn't had COVID.
They used the Asthma Control Test (ACT) for quantifying asthma control. An ACT score of 25 indicates complete asthma control, 20 to 24 indicates well-controlled asthma, 17 to 19 not well-controlled asthma, and 16 or less poorly controlled asthma. The investigators determined that a drop of 3 ACT points or more indicates less asthma control.
The study authors found that COVID-19 was tied to a tripling of the risk for a drop of 3 or more ACT points (adjusted odds ratio [aOR], 3.11), an almost five times higher odds of escalation of asthma therapy by at least 1 Global Initiative for Asthma step—another measure of less asthma control—(aOR, 4.73), and a more than five times higher risk of having uncontrolled asthma overall (aOR, 5.51).
The authors, conclude, "Mild-to-moderate COVID-19 among asthma patients was associated with worsening of asthma symptom, lower ACT score, a greater need for escalation of asthma maintenance therapy, and more uncontrolled asthma after recovery."