A small German study today in Scientific Reports reveals higher levels of post-COVID-19 symptoms and problems in patients who were admitted to the intensive care unit (ICU) compared with non-ICU patients.

The single-center study at the University Hospital of Wuerzburg looked at outcomes for 85 patients hospitalized for COVID-19 from March to December 2020, with patients interviewed 3 and 12 months after discharge about quality of life, lingering symptoms, and mental health following their infection.

Of the 85 patients, 45 patients had critical COVID-19 treated in the ICU. The median age was 61 in ICU patients and 63 in non-ICU patients, but patients admitted to the ICU had a higher body mass index. Roughly half of the ICU patients required high-flow oxygen, and 89% of them were mechanically ventilated.

Coinfections were much more common in ICU patients, with pulmonary coinfections seen in 38% of ICU patents and 5% of non-ICU patients.

At 1 year, 20% of ICU patients unable to perform usual tasks

At both 3 and 12 months post-discharge, ICU patients reported more mobility problems, and at 12 months 20% of ICU patients had severe problems or were unable to perform their usual activities, compared with 13% of non-ICU patients. At 12-month follow-up, 63% of ICU patients and half of the non-ICU patients had not returned to work, with 37% of ICU and 11% of non-ICU patients unable to work because of disability.

Low levels of stress were rarely observed in ICU patients.

One fifth of both patients groups reported depression during follow-up.

"Low levels of stress were rarely observed in ICU patients, indicating that nearly all ICU survivors experience moderate to high levels of stress one-year after discharge," the authors wrote. "Our data highlight the complexity of post-COVID-19 symptoms as well as the necessity to educate patients and primary care providers about monitoring mental well-being."

A survey of patients at urgent-care centers (UCCs) in five states suggests patient satisfaction scores are associated with higher expectation for antibiotics, researchers reported today in Antimicrobial Stewardship & Healthcare Epidemiology.

For the survey, conducted by researchers with George Washington University's Milken Institute School of Public Health, patients and guardians of pediatric patients at 27 UCCs and 5 pediatric UCCS in Colorado, Florida, Georgia, New Jersey, and Texas were asked to complete an anonymous questionnaire that asked about their demographics, expectation for antibiotics (expectation score), treatment plan, and level of satisfaction with their care (satisfaction score).

The expectation score and satisfaction score were measured using a 5-point Likert scale, with 5 representing the highest belief in the need for antibiotics and the highest level of satisfaction. A total of 2,279 questionnaires from general UCCs and 431 from pediatric UCCs were included in the analysis.

The median expectation score was 3.37 among adults and 3.26 among guardians of pediatric patients. Expectation scores did not differ by age, ethnicity, race, or education level for general UCCs, while guardians aged 30 to 49 years had the highest expectation scores at pediatric UCCs. The median satisfaction score was 4.23 for adults and 4.18 for guardians of pediatric patients, with similar scores across sex, age group, ethnicity, and education level.

Antibiotics were prescribed for 53.4% of adult patients and 36.0% of pediatric patients. Logistic regression analysis found that antibiotic prescription had no effect on patient satisfaction among adult patients reporting low expectation scores, but medium-to-very-high expectation scores were associated with higher levels of satisfaction upon receiving antibiotics and with lower levels of satisfaction when antibiotics were not prescribed. No statistically significant association was found for pediatric visits.

Decreasing urgent-care patient expectations and beliefs regarding the need for antibiotics ... may decrease unnecessary prescriptions.

"Our findings suggest that decreasing urgent-care patient expectations and beliefs regarding the need for antibiotics (eg, thoroughly educating patients on the clinical applicability and risks of antibiotic use) may decrease unnecessary prescriptions without negatively impacting patient satisfaction," the study authors wrote.

The UK Health Security Agency (UKHSA) is launching a new study to assess the level of antimicrobial resistance (AMR) in healthy people across England and what drives it.

The study will invite 2,000 people to submit stool samples and nose and throat swabs for analysis by UKHSA scientists, who will be looking to gain a better understanding of the prevalence of antibiotic-resistant bacteria in the general population, including carbapenemase-producing Enterobacteriaceae, extended-spectrum beta-lactamases (ESBLs), and methicillin-resistant Staphylococcus aureus. Scientists will also assess the prevalence of the multidrug-resistant fungus Candida auris.

We will be able to design better ways to tackle AMR in different populations.

The study will also explore whether AMR levels vary by demographics and assess different risk factors for carrying resistant pathogens, including travel, diet, healthcare contact, and household transmission.

"By understanding more about the burden of AMR in healthy people in the general population and the factors that mean someone is more likely to be carrying a resistant organism, we will be able to design better ways to tackle AMR in different populations," Russell Hope, PhD, deputy director of the AMR Division at UKHSA, said in a press release.

A similar study conducted by Public Health England in 2014 found that 7.3% of adults in England carried ESBL-producing Enterobacteriaceae.

Yesterday the World Health Organization (WHO) confirmed three new H9N2 avian flu cases in China, all involving children living in or with connections to Hunan province. The agency also noted two variant H1N1 (H1N1v) flu cases in young Chinese girls.

One H9N2 patient is a 10-year-old girl from Hunan province who fell ill in October 2022. The second is a 2-year-old boy from Hunan province whose symptoms began on February 5 and who had been exposed to backyard poultry before he became sick.

The third child with H9N2 flu is a 3-year-old girl from Jiangxi province who had suspected exposure to backyard poultry in Hunan province. Her symptoms first developed on January 31.

"Avian influenza A(H9N2) viruses are enzootic in poultry in Asia and increasingly reported in poultry in Africa," the WHO said.

H1N1v in preschoolers

The WHO also reported that a 3-year-old girl in Sichuan province and a 1-year-old girl in Jiangsu province contracted H1N1v flu. The older girl became ill December 27, 2022, while the younger one first had symptoms on January 30.

No information on the likely source of exposure to the virus was available.

The agency says the girls were infected with a "Eurasian avian-like swine influenza" strain. Both girls had mild illness and did not require hospital care.

The WHO said, "No information on the likely source of exposure to the virus was available at the time of reporting and no suspected cases among family contacts of the cases were reported."