In a flu pandemic setting, the drug could be used to curb household transmission, especially early in the response, the authors say.
The loss of activity is equivalent to 15% of the US population becoming completely immobile for 1 day.
Adult COVID-19 patients also infected with the flu are 4 times more likely to need mechanical ventilation and 2.4 times more likely to die.
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The weekly proportion of outpatient visits for influenza-like illness, flu hospitalizations, and flu deaths all peaked between the 90th and 98th percentile.
The first phase of work focuses on an antibody that broadly protects against circulating SARS-CoV-2 variants.
Patients infected with A(H1N1)pdm09 were 42% more likely to be admitted to an ICU, 79% more likely to need mechanical ventilation or ECMO, and 25% more likely to die.
Early sharp rises in some South American countries put pressure on healthcare systems.
Wastewater testing rose in prominence during the COVID-19 pandemic.
Flu remained at low levels overall, but with elevated activity in some parts of Asia and Central America.
Flu was tied to 7,851 deaths from week 33, 2022, to week 12, 2023, compared with 32,607 deaths tied to COVID-19.
Southeast Asia's flu levels remained elevated, including in Cambodia, Myanmar, and the Philippines.
Rather than indoor-outdoor air exchanges per hour, the document describes an "equivalent clean air flow" target per occupant of pathogen-free air.
Patients with COVID-19 also saw a sixfold higher rate of in-hospital deaths.
