In a flu pandemic setting, the drug could be used to curb household transmission, especially early in the response, the authors say.
The loss of activity is equivalent to 15% of the US population becoming completely immobile for 1 day.
Adult COVID-19 patients also infected with the flu are 4 times more likely to need mechanical ventilation and 2.4 times more likely to die.
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In its weekly respiratory illness snapshot, the CDC upgraded the level from low to moderate.
But the researchers say other genetic mutations would likely be needed for the virus to prefer human cell receptors and enable efficient human transmission.
But the risk of bacterial infections in COVID-19 patients was substantially elevated after 48 hours compared with the other viruses.
They also had lower odds of requiring intensive care and dialysis or vasopressors than those who didn't receive early therapy, the authors say.
In its annual National Influenza Vaccination Week messaging the CDC said there's still time to benefit from getting a flu shot this season.
With flu and COVID levels still low but expected to rise, the CDC said vaccination is a good way to cut risk over the holiday season.
As flu test positivity crept upward, emergency department visits increased slightly among children and adolescents.
In 2017-18, 70% to 86% of hospitalized children with flu received antivirals, declining to 52% to 59% in 2023-24.
Meanwhile, COVID activity remained low amid a shift in variant proportions and RSV levels rose in 3 US regions.
The average time between discharge and death was 9 days.
