News Scan for May 29, 2020

Drug-resistant bloodstream infections
Ebola vaccine recommendation
Polio in 6 countries

Canadian data show rise in MRSA, VRE blood infections

Data collected from Canadian acute care hospitals show significant increases in methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococci (VRE) bloodstream infections (BSIs) in recent years, according to a study in the Canada Communicable Disease Report (CCDR).

The data, collected from 70 Canadian sentinel hospitals from 2014 through 2018 through the Canadian Nosocomial Infection Surveillance Program, show a 59.1% increase in MRSA BSIs (0.66 to 1.05 infections per 10,000 patient-days) and a 143% increase in VRE BSIs (0.14 to 0.34 infections per 10,000 patient-days).

But Clostridioides difficile infections decreased by 12.5% (from 6.16 to 5.35 infections per 10,000 patient-days). Carbapenem-resistant Enterobacteriaceae infection rates remained low and stable (0.04 infections per 10,000 patient-days), while colonization rates increased by 375% (from 0.04 to 0.19 per 10,000 patient-days).

The authors of the study said the increases in MRSA and VRE BSIs are concerning because of the increased mortality associated with these infections.

"These findings indicate a need for continued vigilance to prevent morbidity and mortality attributable to HAIs [healthcare-associated infections) and AROs [antimicrobial resistant organisms] in the inpatient population," they wrote.
May 28 CCDR study


European advisors recommend approval for 2-dose Ebola vaccine

European vaccine advisors today recommended the approval of Johnson & Johnson's two-dose Ebola vaccine, the European Medicines Agency (EMA) said today.

The European Commission gives final approval, but it usually follows the recommendations of its advisory committee. The vaccine, the second to be approved for Ebola, was introduced for use in the Democratic Republic of the Congo (DRC) in November 2019 as part of a clinical trial. The vaccine's two doses are given 8 weeks apart.

No new cases have been reported in the DRC's outbreak since officials reported a cluster of 7 cases recently in Beni, meaning the total stands at 3,463, the World Health Organization (WHO) said in an update yesterday. So far, no definitive source in the cluster has been found. The outbreak will be considered over if no new cases are reported before Jun 25.
May 29 EMA statement
May 28 WHO


Pakistan, 5 African nations report more polio cases

Six countries reported more polio cases this week, Pakistan with two more wild poliovirus type 1 (WPV1) cases, and five African countries with additional circulating vaccine-derived poliovirus type 2 (cVDPV2) cases, the Global Polio Eradication Initiative (GPEI) said in its latest weekly update.

Pakistan's cases are from Khyber Pakhtunkhwa and Punjab provinces, raising the country's WPV1 total for the year to 49.

In Africa, Ethiopia reported 4 cVDPV2 cases, 1 in Oromiya province and three in the Southern Nations, Nationalities, and Peoples' region, bringing the country's total for the year to 26. Niger and Ghana both reported 3 new cases. Niger's were in Dosso, Niamey, and Tillaberi provinces, raising its number for the year to 4. Of Ghana's 3 cases, 1 of in Ashanti province and 2 are in Western province, bringing its total to 11.

The DRC and Togo each reported 1 more case. The DRC's case is in Kongo Central province and is from November 2019, raising last year's total to 88. So far, it has reported 5 cases this year. Togo's case is in Lomt province, lifting its total for 2020 to 7.
May 27 GPEI weekly update

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