Analysis of more than two decades’ worth of data from 70 countries indicates that gender inequalities influence antibiotic consumption patterns, researchers reported yesterday in the Journal of Antimicrobial Chemotherapy.
For the study, a team led by researchers from the One Health Trust analyzed IQVIA MIDAS data on yearly antibiotic consumption from 70 countries from 2000 through 2002. To assess the influence of gender inequalities, they used four indicators—proportion of women with secondary or higher education, female-to-male labor force participation (FMLP) ratio, proportion of women in parliament, and share of female population—and estimated within-country associations between these indicators and overall antibiotic consumption, controlling for income, education, health care access, health spending, and demographics.
Overall average antibiotic consumption was 19.13 defined daily doses (DDDs) per 1,000 population, with wide variations observed across the 70 countries. Analysis of the relationship between antibiotic consumption and the four gender inequality indicators showed that a one-percentage-point increase in the proportion of women with secondary or higher education was associated with a 0.15 DDD reduction in antibiotic consumption. And a 0.1-unit increase in the FMLP ratio was associated with a 2.45 DDD reduction, while a one-percentage-point increase in the female population share raised antibiotic consumption by an estimated 2.3 DDD.
Women’s parliamentary representation was not associated with antibiotic consumption.
Higher education, workforce participation enhance health literacy
The study authors say the findings highlight gender dynamics as a key social determinant of susceptibility to antimicrobial resistance (AMR).
“Higher education among women likely enhances health literacy, fosters preventive practices such as antenatal care, and promotes rational antibiotic use within households,” they wrote. “Similarly, a higher FMLFP ratio reflects reduced gender inequity and improvements in women’s economic and health empowerment.”
Conversely, they add, the link between a larger female population and higher antibiotic use is likely related to increased health care needs related to pregnancy, urinary tract infections, and longer female life expectancy.
“Overall, this study calls for a multifaceted approach that leverages gender indicators to promote equitable healthcare access, rational antibiotic use, and effective AMR mitigation,” they concluded.