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Researchers also estimate that vaccines averted 27 million infections and 1.6 million hospitalizations.
WHO data show that, among monkeypox patients with known HIV status, 41% are HIV-positive.
A study yesterday in The Lancet Infectious Diseases describes an ongoing outbreak of sexually transmitted, extensively drug-resistant (XDR) Shigella sonnei in the United Kingdom.
The experimental cancer drug sabizabulin slashed all-cause deaths by 55.2% over placebo in high-risk hospitalized COVID-19 patients by 60 days and was tied to fewer adverse events, according to interim results of a randomized, controlled phase 3 trial published yesterday in NEJM Evidence.
The Global Plan to End TB 2023-2030 calls for a global investment of $250 billion.
"Testing remains a challenge, and it's highly probable that there are a significant number of cases not being picked up."
BA.4 and BA.5—which now cause more than 70% of US cases—are 4 times more resistant to 3 vaccine doses than BA.2 is, and only 1 of 19 monoclonal antibodies tested showed efficacy against those subvariants.
In global developments, cases rose for the fourth straight week, led by the BA.4 and BA.5 Omicron subvariants.
Pre-Omicron, the leading causes of death were heart disease (20.1%), cancer (17.5%), and COVID-19 (12.2%).
A study in Ontario suggests that, compared with a third dose of mRNA COVID vaccine, a fourth dose improved protection against infection and severe outcomes among long-term care residents during the Omicron wave. The study was published today in The BMJ.
The odds of having long COVID fell from 48% before vaccines to 16% after a third vaccine dose.
BA.5 now makes up 53.6% of cases, BA.4 makes up 16.5%, and both are highly transmissible.
All but 3 of 52 patients had lesions and rashes on their genitals or anal regions.
A study of US hospital data found that fewer than 10% of COVID-19 patients had bacterial or fungal co-infections, but they had a higher risk of antibiotic-resistant, healthcare-associated infections than flu patients, Centers for Disease Control and Prevention researchers reported late last week in Clinical Infectious Diseases.
A new study shows that the proportion of children diagnosed as having COVID-19 and croup was significantly higher during the Omicron surge than in earlier waves dominated by other variants.
Croup is an upper airway infection generally affecting children. It causes swelling around the larynx, trachea, and bronchi, resulting in labored breathing and a "barking" cough.
Though all benefited, those at lowest and highest body weights were at greater risk, possibly due to differences in immune response.
The mobile units are geared toward reaching high-risk communities and come as the US and other countries battle rising COVID activity.
Europe's cases have tripled over the last 2 weeks, and US cases approach 400, with New Hampshire and Puerto Rico reporting their first cases.
Flu activity is rising in some of the Southern Hemisphere's temperate countries, including Australia, New Zealand, and southern Africa. At the global level, however, levels are declining following a March peak, the World Health Organization (WHO) said in a global flu update that roughly covers the first half of June.
Other areas seeing rises are Chile and southern China, where H3N2 is the dominant strain.
Our weekly wrap-up of antimicrobial stewardship & antimicrobial resistance scans
A study of children hospitalized with community-acquired pneumonia (CAP) suggests that antibiotic decisions made in the emergency department (ED) have a significant impact on inpatient antibiotic use, researchers reported today in Pediatrics.
