
Chinese scientists say they have identified a potentially novel tickborne virus among patients at a hospital in northeastern China.
In a letter published last week in the New England Journal of Medicine, a team led by researchers with Mudanjiang Forestry Central Hospital and the State Key Laboratory of Pathogen and Biosecurity say the virus was identified through metatranscriptomic sequencing of serum samples obtained from 252 patients with fever and recent tick bites from May through July 2023. Phylogenetic analysis revealed the virus, named the Xue-Cheng virus (XCV), belonged to the orthonairovirus genus of the Nairoviridae family but shared less than 75.6% amino acid identity of RNA-dependent RNA polymerase protein with all known orthonairovirus members, indicating a new species. The detection of XCV antigen was confirmed on immunofluorescence assay.
Testing identifies 26 XCV-infected patients
Real-time polymerase-chain-reaction (RT-PCR) testing of serum samples from 792 participants recruited from May through July of 2022 through 2024 identified 26 XCV-infected patients who were negative for other tickborne infections, with clinical manifestations ranging from nonspecific acute fever to severe disease resulting in hospital admission.
The researchers subsequently detected XCV in 6% of Haemaphysalis concinna ticks and 3.2% of Haemaphysalis japonica ticks in the region, and phylogenetic analysis revealed that four XCV genomes from ticks were clustered with human-derived genomes.
"These data suggest an emerging tickborne orthonairovirus species as a cause of febrile illness," the authors wrote.