Rather than relying on reported cases, monitoring populations through blood testing is important for understanding how it spreads and for guiding targeted vaccination.
The test the US Centers for Disease Control and Prevention uses to identify clade I mpox cases is 'most likely not reliable' for detection of the substrain identified in the study, the authors say.
Another mpox study today showed that dose-sparing vaccine administration of the Jynneos vaccine appeared to have worked.
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Severe complications included necrotizing (flesh-eating) skin lesions, lung dysfunction sometimes accompanied by nodules, and secondary infections and sepsis.
Experts conclude that sustained incidence of illness in a few nations, along with underreported detection of cases, was enough to maintain emergency status.
The estimated vaccine effectiveness of one subcutaneous dose of the Jynneos mpox vaccine among men in Israel is 86%.
In a related development, New York City today declared the end of its mpox outbreak, which follows 2 months of low transmission.
The WHO says cases have risen 1%, and, of 11 countries reporting increases, the largest was in Mexico.
Though the findings are promising, researchers are still examining the benefits and drawbacks of the one-dose strategy.
The CDC recorded 466 mpox infections in transgender and gender-diverse adults, which made up 1.7% of adult cases.
The guidance also officially replaces all WHO mentions of "monkeypox" with "mpox," the new official name of the virus.
The disease has historically been defined via household contact, or animal-to-human contact via the ingestion of bushmeat.
The study highlights how easily the disease was misdiagnosed during the initial months of a global outbreak.
