The clade 1 case is the nation's first in a person with no recent travel history and the seventh clade 1 case in the country.
The test the US Centers for Disease Control and Prevention uses to identify clade I mpox cases is 'most likely not reliable' for detection of the substrain identified in the study, the authors say.
Another mpox study today showed that dose-sparing vaccine administration of the Jynneos vaccine appeared to have worked.
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Some of the key steps have included deployment of more community health workers and decentralized lab testing.
The cases in Malawi bring the number of African countries affected by mpox to 23.
Cases are declining in some hot spot countries, as officials warns that nations outside Africa are still reporting imported cases.
The median number of days to lesion clearance was 7 with Tpoxx and 8 with placebo.
In Uganda, the virus is spreading in urban areas and among sexual networks, posing contact-tracing challenges.
Clade 1b is fueling a central Africa mpox outbreak, with the Democratic Republic of the Congo seeing the most cases.
Earlier patients had traveled to outbreak countries or were contacts of earlier cases.
Ghana reported its first recurrence in many weeks, as cases rise in Tanzania and responders launch a second vaccination round in Uganda.
The freeze-dried Jynneos formulation will be easier to store and transport and will have a longer shelf life.
In its monthly mpox update, the WHO said it is tracking several genetic developments, including rising cases of the rare 2b clade.
