In DRC hot spots, vaccination will target the greater community, not just contacts. A trial of the antiviral drug brincidofovir also launched in the country.
The test the US Centers for Disease Control and Prevention uses to identify clade I mpox cases is 'most likely not reliable' for detection of the substrain identified in the study, the authors say.
Another mpox study today showed that dose-sparing vaccine administration of the Jynneos vaccine appeared to have worked.
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Some of the group's concerns include rising case numbers, expanding spread, and response challenges.
The vaccine will allow younger children, vulnerable to infections from household contact, to be immunized.
The California case makes the United States the sixth country outside of Africa to report an imported clade 1 case.
Meanwhile, amid a steep rise in Uganda, health officials have identified new mpox clusters in sex workers.
Meanwhile, Uganda’s outbreak is rapidly expanding, mostly involving intimate close-contact spread and among sexual networks.
The trial will be conducted in the Democratic Republic of the Congo in partnership with Emergent BioSolutions.
In other outbreak developments, medical groups announce a vaccine allocation plan and a vaccine trial to begin in pregnant women and in children younger than 2.
The new UK mpox patient is another member of the index case's household.
Officials say the virus is highly infectious in households with close contact, so the illnesses aren't unexpected.
Clade 1b has spread to more Ugandan provinces, including some fishing communities.
