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Report: Combo therapy outwits challenging infections

… antibiotic ceftazidime/avibactam with the antibiotic aztreonam. Ceftazidime/avibactam, which was approved in the … particularly in Southeast Asia and parts of Europe. Aztreonam, on the other hand, is susceptible to the class A … What Bonomo and his team hypothesized was that if aztreonam were added to the ceftazidime/avibactam combination …
Chris Dall | News Reporter | CIDRAP News
Hand holding in hospital

Phase 3 data support use of combination antibiotic for multidrug-resistant infections

… this week published phase 3 clinical trial data supporting aztreonam-avibactam as a potential therapeutic option for … sudok1 / iStock Jointly developed by Pfizer and Abbvie, aztreonam-avibactam is a beta-lactam/beta-lactamase inhibitor combination that restores aztreonam's activity against gram-negative bacteria that …
Chris Dall

European Medicines Agency approves combination antibiotic for multidrug-resistant infections

… (EMA) has granted marketing authorization for Emblaveo (aztreonam-avibactam) for treating a host of … and Abbvie, Emblaveo combines a beta-lactam antibiotic (aztreonam) with a beta-lactamase inhibitor (avibactam). The combination aims to restore aztreonam's activity against gram-negative bacteria that …
Chris Dall

Combination antibiotic gets boost from European regulators

… the granting of marketing authorization for Emblaveo (aztreonam-avibactam) for treating adults with complicated … Abbvie, Emblaveo combines an old beta-lactam antibiotic (aztreonam) with a newer beta-lactamase inhibitor (avibactam). The combination aims to restore aztreonam's activity against gram-negative bacteria that …
Chris Dall

Combination antibiotic shows promise in two phase 3 trials against superbugs

… findings of the investigational antibiotic combination aztreonam-avibactam. Infectious disease topics Antimicrobial … infections. The results from the two trials indicate that aztreonam-avibactam (ATM-AVI), which combines an old beta-lactam antibiotic (aztreonam) with a newer beta-lactamase inhibitor (avibactam), …
Chris Dall
IV drip with healthcare worker in background

DRUG RESISTANCE SCAN: US NDM isolates, resistant food pathogens in Europe

… The isolates were resistant to beta-lactams, including aztreonam, as well as all commonly used aminoglycosides and …
 

Report highlights the occurrence of beta-lactamase resistance genes in US hospitals

… least two of four antibiotics (ceftazidime, ceftriaxone, aztreonam, or cefepime) or resistance to carbapenems were … 91.9% of the isolates resistant to cephalosporins and/or aztreonam without carbapenem resistance, respectively. The …
Chris Dall

Stewardship / Resistance Scan for Dec 12, 2019

… also note synergistic activity against the strain for aztreonam combined with ceftazidime-avibactam. As noted by …

Stewardship / Resistance Scan for Oct 11, 2019

… were also non-susceptible to cefotaxim, cefepim, and aztreonam and were carrying the extended-spectrum …

Stewardship / Resistance Scan for Jul 26, 2017

… polymyxin B. The three-drug combination of polymyxin B, aztreonam, and amikacin completely eradicated and suppressed …

Stewardship / Resistance Scan for Jul 05, 2022

… siderophore cephalosporins (cefiderocol), monobactams (aztreonam), carboxypenicillins (piperacillin), glycopeptides …

Stewardship / Resistance Scan for Dec 09, 2019

… antibiotics, most often cephalosporins, and that aztreonam and levofloxacin were the most commonly prescribed …

Report highlights gaps in access, stewardship plans for promising antimicrobials

… invasive fungal infections. The fifth product is Pfizer's aztreonam-avibactam, which was recently approved by the … While Pfizer is applying specific pricing strategies for aztreonam-avibactam and has an initiative to offer drugs in …
Chris Dall
access to medicine

Stewardship / Resistance Scan for May 17, 2017

… disease syndromes. The targeted agents were amikacin, aztreonam, cefepime, ceftaroline, daptomycin, doripenem, …

ASP Scan (Weekly) for Dec 13, 2019

… also note synergistic activity against the strain for aztreonam combined with ceftazidime-avibactam. As noted by … antibiotics, most often cephalosporins, and that aztreonam and levofloxacin were the most commonly prescribed …

ASP News Scan for Oct 28, 2016

… to a combination regimen of vancomycin plus aztreonam in reducing lesion size within 48 to 72 hours—and …

FDA approves new antibiotic for multiple bacterial infections

… that Zevtera was noninferior to vancomycin plus aztreonam in terms of early clinical response in adults with …
Chris Dall

Outbreak of highly resistant Pseudomonas linked to eye drops grows to 68

… ceftazidime, cefepime, piperacillin-tazobactam, aztreonam, and ceftazidime-avibactam. Prior to the outbreak, …
Chris Dall

Report: Antibiotic stewardship programs lower infections, improve care

… stewardship with a 4-month study on inappropriate use of aztreonam, tigecycline, daptomycin, and linezolid. Staff …
Natalie Vestin, MPH | News Reporter | CIDRAP
IV antibiotic

News Scan for Oct 25, 2016

… to a combination regimen of vancomycin plus aztreonam in reducing lesion size within 48 to 72 hours—and …

French researchers report emergence of highly resistant Klebsiella strain

… except colistin, cefiderocol, and the combination of aztreonam/avibactam, and 37 of 39 isolates possessed a high …
Chris Dall

US researchers report urinary tract infection caused by pan-resistant E coli

… to both cefiderocol and ceftazidime-avibactam plus aztreonam (CZA-ATM)—the preferred treatment regimens for …
Chris Dall

Tainted eye drops tied to 81 cases of highly resistant Pseudomonas, 4 deaths

… cefepime, ceftazidime, piperacillin-tazobactam, aztreonam, carbapenems, ceftazidime-avibactam, …
Jim Wappes

Multidrug-resistant E coli prevalent in supermarket meat samples in Spain

… highest prevalence of resistance was against ampicillin, aztreonam, nalidixic acid, ceftazidime, and cefuroxime. …
Chris Dall

WHO unveils priority pediatric antibiotic formulation list

… that are in the pipeline: cefepime-zidebactam and aztreonam-avibactam. Familiar development challenges even …
Lisa Schnirring
child antibiotic