A systematic review and meta-analysis of 12 studies suggests meningococcal vaccines show moderate effectiveness against gonorrhea infection, researchers reported yesterday in the Journal of Infection.
Of the 12 studies included in the review, conducted by a team of researchers from Australia, nine evaluated the evidence of vaccine effectiveness (VE) of meningococcal B (MenB) outer membrane vesicle (OMV) vaccines against gonorrhea, and one evaluated VE of a non-OMV-based vaccine (MenB-FHbp)
While previous studies have indicated that the four-component serogroup B meningococcal vaccine (4CMenB) and other OMV-based MenB vaccines, which target Neisseria meningitides, may provide some cross-protection against Neisseria gonorrhoeae, none have synthesized and examined the evidence of the effects of all meningococcal vaccines on gonococcal infections.
Most of the included studies targeted people aged 15 to 30 years in 8 countries: Australia, Canada, Cuba, France, Italy, New Zealand, Norway, and the United States. Six of the studies evaluated the VE of the 4CMenB vaccine. The adjusted VE for OMV-based vaccines against gonorrhea ranged from 22% to 46%. The pooled VE estimates of OMV vaccines against any gonorrhea infection following the full vaccine series were 33% to 34%. The observed vaccine impact (VI) ranged from a 30% reduction in gonorrhea incidence in South Australia to a 59% reduction in Quebec, Canada.
The MenB-FHbp vaccine showed no protection against gonorrhea.
A potential strategy for reducing gonorrhea incidence
The study authors say that while the variation in VE and VI could be attributed to differences in vaccination programs, target age-groups, and the regional epidemiology of gonococcal infections, the findings "provide reassurance regarding the cross-protection provided by MenB vaccines." And with the prevalence of N gonorrhoeae strains with resistance to most commonly used antibiotics on the rise worldwide, and no highly effective, gonorrhea-specific vaccine on the horizon, they suggest vaccines like 4CMenB are "the most favorable approach" to combat the increasing incidence of gonorrhea.
These findings emphasise the potential value of incorporating meningococcal vaccination into strategies aimed at controlling gonococcal infections.
"These findings emphasise the potential value of incorporating meningococcal vaccination into strategies aimed at controlling gonococcal infections, particularly in regions with high incidence rates and limited treatment options due to antibiotic resistance," they wrote.