A new study involving Norwegian nurses links sleep debt and night work to an increased risk of the common cold, with sleep debt also linked to vulnerability to pneumonia/bronchitis, sinusitis, and gastrointestinal infection.

Researchers at Haukeland University Hospital in Bergen examined the association among sleep duration, lack of sleep, shift work, and self-reported infections among 1,335 Norwegian nurses. The average participant age was 41.9 years, and 90.4% were women. The data were derived from the spring 2018 Survey of Shift work, Sleep and Health study.

"Approximately 25% of all employed individuals worldwide are engaged in shift work," the investigators wrote. "While around-the-clock work is crucial for maintaining the functioning of essential services, shift and night work also bring forth diverse health consequences for the workers."

The findings were published yesterday in Chronobiology International. 

Severe sleep debt tied to almost 4 times risk of pneumonia

Relative to adequate sleep, sleep debt (1 to 2 hours or more than 2 hours, respectively) was associated in a dose-dependent manner with an increased risk of the common cold (adjusted odds ratios [aORs], 1.33 and 2.32), pneumonia/bronchitis (aORs, 2.29 and 3.88), sinusitis (aORs, 2.08 and 2.58), and gastrointestinal infection (aORs, 1.45 and 2.45).

Brazil has reported its first clade 1b mpox case, per a notice from the national Health Ministry. 

According to media reports, the patient is a 29 year-old woman from Sao Paulo, whose relative had recently returned from travel to the Democratic Republic of the Congo (DRC). Currently the DRC is in the middle of a large mpox outbreak, with thousands of cases caused by clade 1b, a more transmissible strain of the virus. 

So far this year Brazil has reported 52 cases of mpox, but all were clade 2, the strain that caused a global outbreak of the virus in 2022 and 2023, primarily among men who have sex with men. 

Health Ministry officials said there are no other clade 1b cases in Brazil at this time. 

Grant for single-dose vaccine 

In related news, Tonix Pharmaceuticals today announced that it has received a US Department of Defense grant to support the development of a single-dose vaccine against mpox and smallpox. A grant from the Medical CBRN Defense Consortium will support the development of TNX-801, a recombinant live horsepox virus vaccine.

"TNX-801 offers an appealing target product profile, requiring just a single dose for durable, long-term protection, with favorable shipping and storage requirements. With a significant global unmet need, TNX-801 is in a strong position to make a potential impact towards preventing mpox and controlling mpox epidemics," said Seth Lederman, MD, the president and CEO of Tonix, in a press release from the company. 

The vaccine has performed well in animal challenges with mpox clade 1 infections, the company said.

A study of patients who received fecal microbiota transplantation (FMT) for recurrent Clostridioides difficile infection (rCDI) at six US hospitals identifies the biggest risk factors for subsequent antibiotic use, researchers reported late last week in Open Forum Infectious Diseases.

The study, led by researchers with the University of Minnesota, was a secondary analysis of a prospective cohort study of patients who received FMT for rCDI from July 2019 through November 23, 2023. 

FMT involves the transfer of stool from healthy donors to help restore the gut microbiome of patients with rCDI, which occurs in roughly 20% of CDI patients after an initial infection and becomes more of a risk with each subsequent episode. Although FMT has been shown to be effective as an rCDI treatment and is endorsed by several medical societies for managing rCDI, the researchers wanted to investigate non-CDI antibiotic exposure in the patients within 2 months of FMT, as that could disrupt the restoration of the gut microbiome and contribute to recurrence.

The analysis included 448 patients from the original study. Of those patients, 82 (19%) were immunocompromised, 147 (34%) had been previously hospitalized for CDI, and 49 (11%) were exposed to non-CDI antibiotics within 2 months of FMT. The most commonly reported reasons for non-CDI antibiotic administration were urinary tract infections, respiratory tract infections, and procedural prophylaxis.

A 'potentially modifiable' risk factor

Risk factors for non-CDI antibiotics within 2 months of FMT included immunocompromised status (odds ratio [OR], 2.2; 95% confidence interval [CI], 1.1 to 4.4), more than three non-CDI antibiotic courses pre-FMT (OR, 3.1; 95% CI, 1.4 to 6.8), and prior hospitalization for CDI (OR, 2.0; 95% CI, 1.1 to 3.8).

The study authors say the findings highlight the importance of appropriate and judicious antibiotic use post-FMT.

"Unlike other risk factors for CDI recurrence, the administration of non-CDI antibiotics post FMT is a potentially modifiable risk factor," the study authors wrote. "Assessment of these risk factors along with understanding the initial triggering event for CDI can help develop a comprehensive plan to prevent subsequent CDI episodes."

In an update on March 8 the World Health Organization (WHO) shared new details about a second cluster of cases—three confirmed and two probable—in Uganda’s Ebola Sudan outbreak, which have raised concerns about undetected transmission and have led to ramped up surveillance.

All of the cases have links to a 4-year-old child, reported as the tenth case, whose confirmed death from the virus occurred on February 25. The WHO’s African regional office last week reported that the boy’s mother had died of an acute illness after delivering a baby in the hospital. The baby also died. Neither were tested, and both fatal illnesses were recorded as probable cases. The report notes that the mother and baby were from Ntoroko district in the west of the country, not far from the Democratic Republic of the Congo (DRC) border.

Unsupervised burial in 3 recent deaths

The WHO said the mother was pregnant when her symptoms began on January 22. She died on February 6, and her newborn child died on February 12. “The three deaths did not have a supervised burial,” the WHO said.

The eleventh confirmed case involves a woman who had contact with the boy, and the twelfth is a woman who had contact with his mother. Both are admitted to Ebola treatment centers.

As of March 2, 192 new contacts have been identified and are under monitoring in connection to the second cluster of cases. The contacts are from Kampala and Wakiso district in the east of the country around the capital city of Kampala, while others are from Ntoroko district in the west.

The outbreak marks Uganda’s sixth Ebola Sudan outbreak. Currently, the case fatality rate is 29%, which is lower than the 41% to 70% levels seen in earlier outbreaks.

For the first time, chronic wasting disease (CWD) has been found on a Kaufman County, Texas, deer farm, the Texas Parks and Wildlife Department (TPWD) reported today.

Two white-tailed deer, a 20-month-old male and an 8-month-old female, tested positive for the fatal neurologic disease during required CWD surveillance. Kaufman County is in the northeastern part of the state, just outside of Dallas.

"Permitted deer breeding facilities must test all mortalities within the facility and conduct ante-mortem testing on any deer prior to movement from the facility, in compliance with surveillance and testing requirements," TPWD said in the news release. "This positive facility and its premises were placed under a quarantine by Texas Animal Health Commission (TAHC) to help prevent spread of disease from the facility."

Infectious prions can withstand heat, radiation, formaldehyde

The first case of CWD in Texas was identified in 2012 in free-ranging mule deer in the Hueco Mountains near the border with New Mexico. Since then, the disease has been detected in Texas captive and free-ranging cervids, including white-tailed deer, mule deer, red deer, and elk.

Permitted deer breeding facilities must test all mortalities within the facility and conduct ante-mortem testing on any deer prior to movement from the facility, in compliance with surveillance and testing requirements.

CWD is caused by infectious misfolded proteins called prions, which can spread from cervid to cervid through body fluids such as saliva, urine, and feces. Once excreted into the environment, prions can persist for years and withstand high levels of heat, radiation, and formaldehyde. 

Since its first detection in a captive mule deer in 1967 in Colorado and a wild deer in 1981, CWD has been found in 36 US states, five Canadian provinces, Finland, Norway, South Korea, and Sweden.