At eight months of follow-up, Jynneos recipients not vaccinated against smallpox had lower binding antibody concentrations than those with infection.
The test the US Centers for Disease Control and Prevention uses to identify clade I mpox cases is 'most likely not reliable' for detection of the substrain identified in the study, the authors say.
Another mpox study today showed that dose-sparing vaccine administration of the Jynneos vaccine appeared to have worked.
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Parties, bath houses, saunas, and other mass-gathering sites have been implicated in transmission.
WHO data show that, among monkeypox patients with known HIV status, 41% are HIV-positive.
"Testing remains a challenge, and it's highly probable that there are a significant number of cases not being picked up."
All but 3 of 52 patients had lesions and rashes on their genitals or anal regions.
Europe's cases have tripled over the last 2 weeks, and US cases approach 400, with New Hampshire and Puerto Rico reporting their first cases.
In US developments, the CDC reported dozens more cases and Texas reported community spread of the virus.
WHO director says he's worried monkeypox could spread to children and pregnant women.
Also, "Many individuals are presenting with atypical symptoms," the WHO says.
As cases top 4,000 worldwide, WHO consultants take a wait-and-see approach.
The number of genetic substitutions is 6 times higher than expected for an orthopoxvirus.
